ABSTRACTS - World Psychiatric Association

PO1.134.
VALPROATE-RISPERIDONE VS. VALPROATE-
LITHIUM COMBINATION IN ACUTE MANIA
M. Barekatain, A. Fatemi, M. Salehi
Isfahan University of Medical Sciences, Isfahan, Iran
We evaluated the efficacy of valproate plus risperidone vs. valproate
plus lithium combination in the treatment of acute mania. In a 2-week,
randomized, double-blind, parallel group study, 46 acute manic
patients according to DSM-IV criteria were randomly assigned to
receive the combination of valproate 20 mg/kg/day plus risperidone 2-
4 mg/day (n=23) or lithium 600-1200 mg/day (n=23). The assessment
of efficacy was made using the Young Mania Rating Scale (YMRS) and
the Clinical Global Impression-Severity (CGI-S) and Improvement
(CGI-I) scale. Other effectiveness measures included YMRS response
(YMRS reduction >50%) and YMRS remission (YMRS total score
£12). In each group, 16 of 23 patients (70%) completed the study.
YMRS response, CGI-Improvement, and reduction in total scores of
YMRS and CGI-S were significantly greater in the valproate-risperidone
than in the valproate-lithium group (p=0.006, p=0.015, p=0.004,
and p=0.007, respectively). There was no significant difference concerning
YMRS remission (p=0.073). The YMRS total score on days 4,
8 and 14 of trial was lower in the valproate-risperidone than in the valproate-lithium
group (p=0.017, p=0.005, and p=0.004, respectively).
The rate of adverse events and the mean weight gain in the two groups
were not statistically different. These data suggest that, in acute manic
patients, the valproate-lithium and the valproate-risperidone combinations
are both effective, but the valproate-risperidone combination
has a more significant impact.
PO1.135.
EFFICACY OF LAMOTRIGINE AS MONOTHERAPY
IN PATIENTS WITH BIPOLAR I DISORDER
S. Uzun, O. Kozumplik, M. Jakovljevic, D. Ljubicic
University Department, Vrapce Psychiatric Hospital; University
Department, Clinical Hospital Zagreb; School of Medicine,
University of Zagreb, University Department, Clinical Hospital
Rijeka; School of Medicine, University of Rijeka, Croatia
The study was aimed to explore the efficacy of lamotrigine as
monotherapy in patients with bipolar I disorder. The sample included
19 patients (8 males and 11 females, aged 18-65 years), with a diagnosis
of bipolar I disorder according to the DSM-IV-TR. All patients
were outpatients. This was the first treatment with lamotrigine for all
patients. Patients were switched to lamotrigine due to side effects of
previous treatment and/or patient’s request. The Clinical Global
Impression (CGI), Young Mania Rating Scale (YMRS) and Montgomery-Asberg
Depression Scale (MADRAS) were used in order to
assess efficacy of the therapy. Also, Patient’s Preference Scale (PPS)
was used in order to evaluate patients’ satisfaction with therapy. The
first assessment was made prior to initiation of the treatment. The following
assessments were made every two weeks. The period of investigation
was three months. Results were statistically analyzed using
methods of descriptive statistics and chi-square test. Statistical significance
was set to p