International Clinical Epidemiology Network - The INCLEN Trust
International Clinical Epidemiology Network - The INCLEN Trust
International Clinical Epidemiology Network - The INCLEN Trust
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<strong>International</strong> <strong>Clinical</strong> <strong>Epidemiology</strong> <strong>Network</strong><br />
THE <strong>INCLEN</strong> TRUST<br />
<strong>INCLEN</strong> Executive Offices<br />
F1/5, 2 nd Floor,<br />
Okhla Industrial Area, Phase-1,<br />
New Delhi - 110020<br />
India<br />
T: +91-11-47730000<br />
F: +91-11-47730001<br />
E: ieodelhi@inclentrust.org<br />
1420 Walnut Street<br />
Suite 411<br />
Philadelphia, PA 19102-4003,<br />
USA<br />
T: +1-215-222-7700<br />
F: +1-215-222-7741<br />
E: inclen@inclen.org
• Founded in 1980 by the Rockefeller Foundation to promote clinical<br />
epidemiology as a “bridge” discipline between medicine and public<br />
health<br />
• Phase I: master’s level training provided for fellows from<br />
developing countries at training centers in the USA, Canada &<br />
Australia<br />
• Phase II: training of fellows in new master’s programs established<br />
in developing countries<br />
• Established <strong>INCLEN</strong>, Inc. as an independent 501(c)3 organization in<br />
1989
<strong>INCLEN</strong> Transformation<br />
• External Evaluation of <strong>INCLEN</strong> 1999<br />
– Expansion of mandate beyond training and clinical care<br />
centered research<br />
– Revised research capacity building strategy<br />
– Greater use of population and community based<br />
approaches<br />
– Translating research findings<br />
– Expansion of membership<br />
• North to South Transition of action
<strong>INCLEN</strong> <strong>Trust</strong> Governance: 2000<br />
Southbased<br />
Board of Governors<br />
Executive Office<br />
Board of <strong>Trust</strong>ees<br />
(CLEN presidents, <strong>INCLEN</strong> Inc. Brd reps, others)
<strong>INCLEN</strong><br />
Regional<br />
<strong>Network</strong>s
<strong>INCLEN</strong> Governance<br />
Board of <strong>Trust</strong>ees (BOT)<br />
5 Independent Members + 7 Regional CLEN Presidents<br />
Executive Office (Secretariat)<br />
Executive Director<br />
+ Program Teams + Policy Advocacy Team + Grant , Finance & Admin Team<br />
Regional CLENs
<strong>INCLEN</strong> Operation<br />
• IEO at Philadelphia<br />
• IEO at Delhi<br />
• Both the offices make us functional 24<br />
hours<br />
• Synergistic and complementary<br />
• Not-for-Profit status<br />
• Organized fund transfer mechanism to any<br />
part of world
<strong>INCLEN</strong> Strategic Plan<br />
Strengthen<br />
<strong>INCLEN</strong>’s global,<br />
regional and<br />
national research<br />
and capacity<br />
building functions<br />
Develop a<br />
Matrix <strong>Network</strong><br />
and Foster<br />
<strong>Network</strong>ing and<br />
Partnership at<br />
various levels<br />
Sustain and<br />
create new<br />
programs in:<br />
High priority<br />
health problems<br />
in developing<br />
countries<br />
Create Virtual<br />
Campus<br />
Achieve financial sustainability for <strong>INCLEN</strong>’s infrastructure
<strong>INCLEN</strong>’s Vision<br />
Program<br />
Policy<br />
Individual<br />
“Bridges” between<br />
Clinicians & Public Health<br />
Research<br />
Institutions<br />
Capacity Building
<strong>INCLEN</strong>’s Vision- Revised<br />
Individuals<br />
Program<br />
Collaborative<br />
Interdisciplinary<br />
Research<br />
Policy<br />
High Priority Health Problems<br />
- Impact<br />
- <strong>Network</strong> growth<br />
Building<br />
“Bridges”<br />
between<br />
Clinicians &<br />
Public Health<br />
Research<br />
Institutions<br />
Capacity Building linked<br />
to research programs
Dynamics of Collaborative Research Work<br />
Donors<br />
Policy<br />
Makers<br />
IPEN<br />
PMC<br />
<strong>INCLEN</strong>
Major thrust areas<br />
• Maternal and child health research<br />
• Immunization<br />
• Nutrition<br />
• Program evaluation<br />
• Health System and Social and behavioral research<br />
• Patient safety<br />
• Disease surveillance<br />
• Capacity Building<br />
• Technical assistance to government<br />
• Policy advocacy
Knowledge Translation effort<br />
• Research to Policy translation effort<br />
• Partnership with Policy makers and program<br />
managers<br />
• Representation in key policy making platforms and<br />
bodies<br />
• Publications and dissemination<br />
• Participation in National and <strong>International</strong><br />
consultation
<strong>The</strong> spectrum<br />
• <strong>INCLEN</strong> global <strong>Network</strong><br />
• IPEN- IndiaCLEN Program Evaluation <strong>Network</strong><br />
• NCCPE- National Certification Committee for Polio<br />
Eradication<br />
• MCH STAR<br />
• CHNRI<br />
• McGill Think Tank
IndiaCLEN Program Evaluation<br />
<strong>Network</strong> (IPEN)<br />
How we started….<br />
• 1995-1996: Pulse Polio Program was started in the<br />
country.<br />
• <strong>The</strong>re was a requirement to evaluate the program<br />
throughout the country.
IndiaCLEN Members -1996<br />
♦ Delhi<br />
Lucknow<br />
♦<br />
♦<br />
Nagpur<br />
N = 6<br />
♦<br />
♦♦<br />
Chennai<br />
Vellore<br />
Thiruvananthapuram
Srinagar<br />
•<br />
IndiaCLEN Program Evaluation<br />
<strong>Network</strong> - 1997<br />
Jodhpur<br />
Ahmedabad<br />
♦<br />
Delhi<br />
Ballabhgarh<br />
Agra<br />
• • • Lucknow<br />
♦<br />
•<br />
Patna<br />
•<br />
Bhopal<br />
Burdwan<br />
•<br />
•<br />
Bilaspur<br />
•<br />
♦<br />
•<br />
Nagpur<br />
• Berhampur<br />
Mumbai•<br />
Gulbarga<br />
Panaji•<br />
•<br />
•<br />
•<br />
Bangalore<br />
♦<br />
♦<br />
Vellore<br />
Calicut • •<br />
♦<br />
Tirupati<br />
Madurai<br />
Thiruvananthapuram<br />
Chennai<br />
Dibrugarh<br />
N = 24
Family Health Awareness Campaign<br />
• Needs assessment and<br />
• Concurrent program evaluation
Srinagar<br />
•<br />
IndiaCLEN Program Evaluation<br />
<strong>Network</strong> - 2000<br />
Kangra<br />
•<br />
Rohtak •<br />
Delhi<br />
♦<br />
Ballabhgarh • Jodhpur<br />
Agra<br />
Lucknow<br />
Dibrugarh<br />
Bikaner • Jaipur<br />
•<br />
Kota•<br />
• ♦<br />
Gwalior • • Darbhanga<br />
Kanpur<br />
Patna<br />
• • • •<br />
Guwahati<br />
Agartala<br />
Bhopal<br />
Burdwan<br />
Ahmedabad<br />
• • ••<br />
Jamnagar<br />
• •<br />
•<br />
Aizwal<br />
Bilaspur<br />
• ♦ •<br />
• Kolkata<br />
Sambhalpur<br />
•<br />
Nagpur<br />
Berhampur<br />
•<br />
Cuttack<br />
•<br />
Mumbai•<br />
•<br />
Gulbarga<br />
•<br />
Hyderabad<br />
Panaji•<br />
•<br />
Vijayawada<br />
• Tirupati<br />
Bangalore•<br />
♦Chennai<br />
Kannur •<br />
♦<br />
Vellore<br />
Calicut Madurai<br />
• •<br />
♦<br />
Thiruvananthapuram<br />
Kohima<br />
Imphal<br />
N = 45
Srinagar<br />
•<br />
IndiaCLEN Program Evaluation<br />
<strong>Network</strong> - 2002<br />
Kangra<br />
Chandigarh •<br />
Delhi ♦<br />
• Ballabhgarh • • Dehradun<br />
<br />
Agra<br />
Bikaner • • Lucknow<br />
Dibrugarh<br />
Jodhpur<br />
• • Jaipur<br />
Kota ♦<br />
• • Gwalior<br />
• Darbhanga Patna<br />
• •<br />
Guwahati • •<br />
Udaipur<br />
•Kanpur<br />
• Varanasi<br />
Bhopal<br />
Burdwan • • ••<br />
Agartala<br />
•<br />
Aizwal<br />
•<br />
Bilaspur<br />
• ♦ •<br />
• Kolkata<br />
Surat•<br />
Sambhalpur<br />
•<br />
Nagpur<br />
Cuttack<br />
Bhubaneshwar<br />
Mumbai •<br />
• •<br />
Berhampur<br />
Hyderabad<br />
•<br />
Gulbarga<br />
•<br />
• Visakhapatnam<br />
Panaji • • Vijayawada<br />
Manipal • Tirupati<br />
•<br />
Bangalore•<br />
♦♦<br />
Chennai<br />
Kannur Vellore<br />
Calicut • • Coimbatore<br />
Jamnagar<br />
♦<br />
Thiruvananthapuram<br />
Kohima<br />
Imphal<br />
• Nalgonda N = 51
Assessment of Injection Practices in India<br />
• Nationwide survey<br />
• Impact on Policy and Practice<br />
Baseline assessment of Impact of IMNCI<br />
• For assessing state of child health<br />
• 8 States, 16 Districts
Medical colleges 109<br />
Pub Health Inst 13<br />
NGOs 11<br />
Universities 2
NCCPE (National Certification Committee<br />
for Polio Eradication)<br />
• A Sustained involvement with national polio<br />
eradication program since 1997<br />
– For nationwide assessments<br />
– Key Policy and program inputs<br />
• NCCPE: Monitoring body set up by Ministry<br />
of Health, Govt. of India for polio eradication<br />
program<br />
• Secretariat is at IEO-Delhi
CHNRI (Child Health and Nutrition<br />
Research Initiative)<br />
• CHNRI Secretariat is based at <strong>INCLEN</strong><br />
• Global collaboration for child health &<br />
nutrition research<br />
• Involvement in<br />
– Framing Research priorities in child health and<br />
nutrition at global level<br />
– Policy advocacy initiatives<br />
– Funding
National Immunization Program &<br />
AEFI Surveillance<br />
• Executive Director, <strong>INCLEN</strong><br />
– Member of National Technical Advisory Group on<br />
Immunization (NTAGI)<br />
– Chairperson of National AEFI Committee<br />
• IEO working closely with MOHFW to setup<br />
surveillance and monitoring of AEFI in India
Indian Council of Medical Research &<br />
<strong>INCLEN</strong><br />
• MOU between ICMR & <strong>INCLEN</strong> for<br />
– Joint Research Program<br />
– Health Research Capacity Building<br />
• <strong>INCLEN</strong> represented on key policy making bodies of<br />
ICMR<br />
– Scientific Advisory Board<br />
– Task Force Committees<br />
– Project Review Committee of<br />
• RHN division<br />
• NCD division<br />
• ECD division
MCH STAR Linkage<br />
• A partner in the USAID led MCH STAR initiative<br />
along with PHFI, PFI<br />
• Linkage with Boston University<br />
• Undertaking Operational and Applied Research,<br />
Technical Assistance to State Governments and<br />
Policy Advocacy efforts<br />
• Major research activities are being done by IEO &<br />
IPEN
Policy Advocacy Cell at <strong>INCLEN</strong><br />
• Aiming at pushing the research to policy translation<br />
• At National and State government level<br />
• Through preparing and disseminating policy briefs,<br />
consultations and white papers<br />
• Through the Academia route and reach also<br />
• Effort will be compounded with the CHNRI<br />
advocacy mandate
Key Linkages-<br />
Universities/ Institutes/ Associations<br />
• ICMR<br />
• JHU<br />
• BU<br />
• SFU<br />
• McGill Univ<br />
• McMaster Univ<br />
• UPenn<br />
• PHFI<br />
• Samueli Foundation<br />
• IEA<br />
• InDepth
Some Key <strong>International</strong> Multicentric Studies<br />
• INTU-Association of Intestinal intussusceptions of diarrhea- Six<br />
country surveillance (Brazil, Egypt, Ethiopia, India, Philippines and<br />
Kenya)<br />
• Zinc Supplementation for Children with acute diarrhea: a randomized<br />
trial in five countries (Brazil, Egypt, Ethiopia, India and Philippines)<br />
• Danger Signs of neonatal illnesses: Perceptions of caregivers and<br />
health workers: A Multicentric Study (Brazil, Cameroon, Colombia,<br />
Egypt, India, Indonesia, Philippines)<br />
• APPIS—Multicentric Observational Study to Assess the Safety of<br />
outpatient Treatment of Severe Pneumonia with Oral Amoxicillin in<br />
Children aged 3 to 59 months: A Pilot Safety Study-Six countries<br />
(Bangladesh, Bolivia, Brazil, Egypt, Ghana and Vietnam)<br />
• WorldSAFE & IndiaSAFE: Studying the Prevalence of Family Violence-<br />
Five countries (India, Philippines, Egypt, Chile and Brazil)
Some key Multicentric Studies in India<br />
• IMNCI evaluation- Baseline Survey<br />
• ISCAP- IndiaCLEN Short Course Amoxicillin <strong>The</strong>rapy for Pneumonia<br />
• <strong>The</strong> IndiaCLEN Invasive Bacterial Infection Surveillance (IBIS) Study:<br />
<strong>The</strong> Burden of Vaccine Preventable Illness (IBIS)<br />
• Community Anti Microbial Resistance Study<br />
• Assessment of Injection Practices in India.<br />
• Model Injections Centers in India<br />
• Vitamin-A and Iron folic acid Supplementation<br />
• Evaluation of AFP Surveillance & UIP in India<br />
• IndiaCLEN Concurrent Evaluation of Family Health Awareness<br />
Campaign<br />
• IndiaCLEN Coverage/Process/ Concurrent Evaluation of Family Health<br />
Awareness Campaign<br />
• Pulse Polio Immunization Program Evaluation
Some IPEN Studies<br />
Title Year Funding Source<br />
Pulse Polio Immunization Program (PPI-1) 1997- 98 USAID/<strong>INCLEN</strong><br />
Pulse Polio Immunization Program (PPI-2) 1998 - 99 USAID/<strong>INCLEN</strong><br />
Intensive Pulse Polio Immunization Program (PPI-3) 1999-2000 USAID/<strong>INCLEN</strong><br />
Family Health Awareness Campaign (FHAC-1) 1999 USAID/<strong>INCLEN</strong><br />
Barriers in Polio Eradication (Moradabad, UP) 2000 WHO/SEARO<br />
Family Health Awareness Campaign (FHAC-2)<br />
(Coverage & Process)<br />
2000 - 01 USAID/<strong>INCLEN</strong><br />
Vitamin-A and Iron Folate Supplementation Programs 2001 - 02 Micronutrient<br />
Initiative<br />
Concurrent Evaluation of Family Health Awareness Campaign 2002 NACO<br />
Integrated Disease Surveillance Program: Barriers in<br />
Surveillance Activities in three States (pilot- FGDs)<br />
2001 - 02 World Bank<br />
Assessment of Injection Practices in India 2002 - 04 World Bank & MOH<br />
Evaluation of Universal Immunization Program in India 2004-05 USAID/<strong>INCLEN</strong><br />
Model Injection Centers (MICs): A Program to Improve Injection<br />
Practices in the Country<br />
Integrated Management of Neonatal & Childhood Illnesses:<br />
Baseline Assessment of Childhood Morbidity & Mortality in<br />
selected districts in India<br />
2005-2008 USAID/<strong>INCLEN</strong><br />
2006-2010 UNICEF/ USAID/ WB
Other Research Efforts in India<br />
• Prevention of neonatal sepsis<br />
• Home oral Amoxycillin for severe pneumonia<br />
• Multidrug resistant Tuberculosis<br />
• Surveillance<br />
– Maharastra (Nagpur)- Neonatal Disease<br />
surveillance<br />
– Haryana (Palwal)- Nutrition related chronic<br />
disease surveillance<br />
– Uttar Pradesh (Shivgarh)- Neonatal Disease<br />
Surveillance
Current Operational and Applied Research<br />
Activities<br />
• Determinants of undernutrition in 6 states<br />
• Evaluation of JSY in Jhakhand<br />
• Neurodevelopmental disability in children in India<br />
• Childhood Obesity in India<br />
• Achieving MDG5: Pilot Study into Governance of<br />
Health Systems in Ethiopia
IndiaCLEN/ <strong>INCLEN</strong> Health Research<br />
Capacity Building Initiative<br />
• “Learning-By-Doing” Paradigm<br />
• Younger faculty – co-opted in “ongoing” projects<br />
• Structured Mentoring (National & <strong>International</strong><br />
Members)<br />
• Face-to-face Workshops<br />
– Research Methodology<br />
– Leadership and Management<br />
– Advocacy & Knowledge Translation<br />
• Distance learning<br />
– IGNOU<br />
– SGPGI - Telemedicine
Crafting A Multi-sectoral Platform for<br />
Prevention & Control of Chronic Diseases in<br />
India<br />
• Partnership Initiative between ICMR & <strong>INCLEN</strong><br />
• Technical and Catalytic Support from McGill Health<br />
Challenge Think Tank
Organizational Strengths:<br />
Financial & Administration Systems<br />
• A separate department<br />
– Finance<br />
– Administration<br />
– Grants Management<br />
– HR Management<br />
– Protocol & Liason<br />
• Internal and External Auditors<br />
• Lawyer on relationship basis<br />
• Well laid out SOPs and Communication Channels
Organizational Strengths…<br />
• Infrastructure:<br />
5000 sqt – modern office with state of act<br />
communication facilities (developing videoconferencing<br />
facilities)<br />
• Equipment<br />
• Manpower
Organizational Strengths<br />
Grant Management<br />
• Over 25 years of experience<br />
• USAID / WHO / Rockefeller funds managed<br />
• Currently<br />
• IPHIDE (USAID)<br />
• SAPNA (GAVI)<br />
• Multi-Centric Studies<br />
• Managing Grants for upto 85 partners<br />
• Upcoming<br />
• CHNRI
Why <strong>INCLEN</strong> <br />
• <strong>The</strong> motive<br />
• <strong>The</strong> mandate<br />
• <strong>The</strong> presence<br />
• <strong>The</strong> people<br />
• <strong>The</strong> track record<br />
• <strong>The</strong> system
<strong>INCLEN</strong> have<br />
• Credibility in health research<br />
• <strong>The</strong> network strength<br />
• Experience as funding agency<br />
• Well functioning fund receipt and disbursal channel<br />
• Sound financial management system<br />
• Linkages with the government in Indian context
<strong>INCLEN</strong><br />
A <strong>Network</strong> for<br />
Opportunities and Partnerships
THANK YOU<br />
www.inclentrust.org
<strong>INCLEN</strong> Vision<br />
To attain equity in health for development<br />
To attain equity in health for development<br />
through essential research and training in<br />
clinical epidemiology and related disciplines
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