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Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...

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Purified ATI triggers <strong>in</strong>flammation via TLR4<br />

5 *<br />

4<br />

3<br />

Monocyte derived DCs<br />

*<br />

*<br />

*<br />

*<br />

3 wildtype<br />

C3H/HeJ<br />

2<br />

TLR4 wt and KO mice fed ATI<br />

2<br />

1<br />

*<br />

*<br />

1<br />

0<br />

0<br />

ATI 50g<br />

LPS and ATI: 2.5 nmol/ mouse<br />

C3H/HeJ: TLR4-/- due to a spontaneous<br />

po<strong>in</strong>t mutation<br />

Junker Y et al, 2011

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