Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...
Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...
Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...
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The <strong>in</strong>nate immune<br />
response to gluten<br />
gliad<strong>in</strong><br />
PAMPs<br />
Major role <strong>of</strong> pr<strong>of</strong>essional<br />
APC <br />
Is it all gluten <br />
NKG2D (CD94)<br />
TCR+<br />
MIC-A/B<br />
HLA-E E NKG2A+ TCR+<br />
→ CTL suppression<br />
Bhagat G et al, JCI 2008<br />
NK-like<br />
IL-15<br />
IL-15<br />
CTL<br />
epithelial cell kill<strong>in</strong>g,<br />
apoptosis, permeability <br />
potentiation <strong>of</strong> the adaptive<br />
immune response to gluten<br />
TCR+<br />
CD8+<br />
<strong>in</strong>terferon , perfor<strong>in</strong><br />
granzyme, F<strong>as</strong>L<br />
IL-15:<br />
• central growth<br />
factor for<br />
<strong>in</strong>traepithelial NK<br />
cells and CTL<br />
• major driv<strong>in</strong>g force<br />
<strong>of</strong> clonal T cell<br />
expansion <strong>in</strong><br />
refractory sprue &<br />
<strong>in</strong>test<strong>in</strong>al T cell<br />
lymphoma<br />
Jabri B et al, G<strong>as</strong>troenterology 2000<br />
Maiuri L et al, Lancet 2003<br />
Hue S et al, <strong>Immunity</strong> 2004<br />
Meresse B et al, <strong>Immunity</strong> 2004<br />
Rakhimova M et al, J Cl<strong>in</strong> Immunol 2008
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