Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...

More documents

Recommendations

Info

„gluten sensitivity“ without DQ2/8 and celiac auto-Abs Verdu EF et al, Am J Gastroenterol 2009
Role of the Innate Immune System in celiac disease – prior work • Stimulation of biopsies from CD patients with whole gliadin digests or α2 gliadin p31-43 increases the number of IL-15 positive cells within the lamina propria (Maiuri et al, Lancet 2003) • p31-43 induces MICA on intestinal epithelial cells via IL-15, providing a target for cytotoxic IELs (Hue et al, Immunity 2004) • Peptic-tryptic tryptic gliadin digests and certain gliadin peptides induce activation and maturation of monocytes, , macrophages and dendritic cells (Tuckova Tuckova et al, J Leuk Biol 2002; Palova-Jelinkova et al, FEBS Lett 2004; Nikulina et al, J Immunol 2004; Palova-Jelinkova et al. J Immunol., 2005; Cinova et al, J Clin Immunol 2007; Rakhimova et al., J Clin Immunol 2008) • Gliadin increases intestinal permeability and induces DC activation via MyD88 (implication of CXCR3 on intestinal epithelial cells as gliadin receptor) (Thomas et al., J Immunol., 2006; Lammert et al, Gastroenterology 2008) Problems: 1. LPS contamination not strictly ruled out 2. No reproducible identification of a certain (set of) gliadin peptide(s) 3. No receptor identified
Page 1 and 2: Wheat Amylase Trypsin Inhibitors as
Page 3: Definition of non-celiac gluten sen
Page 7 and 8: Wheat amylase-trypsin inhibitors (A
Page 9 and 10: Characteristics and functions of ce
Page 11 and 12: Allergen as TLR4 agonist 2nd allerg
Page 13: Celiac disease Cd is the best defi

Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...

Create successful ePaper yourself

Delete template?

Save as template?