Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...
Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...
Wheat Amylase Trypsin Inhibitors as Divers of Innate Immunity in ...
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Celiac dise<strong>as</strong>e<br />
Cd is the best def<strong>in</strong>ed and most frequent <strong>in</strong>test<strong>in</strong>al (auto-)<br />
immune dise<strong>as</strong>e, with gluten (and ATI) <strong>as</strong> triggers, HLA-<br />
DQ2 (DQ8) <strong>as</strong> necessary genetic predisposition and TG2<br />
<strong>as</strong> patho-genetically<br />
l<strong>in</strong>ked autoantigen<br />
<br />
Most c<strong>as</strong>es are not <strong>as</strong>sociated with diarrhea or overt<br />
malabsorption, but are silent or atypical<br />
<br />
Dise<strong>as</strong>e severity depends on 1. gluten dose, 2. HLA-<br />
DQ2(DQ8)-gene dose, 3. <strong>in</strong>nate immunity (triggered<br />
by<br />
ATIs), , 4. 4<br />
. additional polygenetic and environmental factors<br />
<br />
<strong>Innate</strong> immunity to cereal ATI likely impacts other<br />
<strong>in</strong>test<strong>in</strong>al <strong>in</strong>flammatory dise<strong>as</strong>es
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