ADVAIR DISKUS ADVAIR - GlaxoSmithKline
ADVAIR DISKUS ADVAIR - GlaxoSmithKline
ADVAIR DISKUS ADVAIR - GlaxoSmithKline
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Partition Coefficient:<br />
The partition coefficient between n-octanol and water is pH dependent and has been<br />
determined by an HPLC procedure.<br />
log D = 3.2 (pH 9.2)<br />
log D = 2.0 (pH 7.4)<br />
log D = 0.6 (pH 4.0)<br />
Drug Substance<br />
Proper name: fluticasone propionate<br />
Chemical name: s-fluoromethyl 6α ,9α-difluoro-11β-hydroxy-16α-methyl-3-oxo17αpropionyloxyandrosta-1,4-diene-17β-carbothioate<br />
Molecular formula and molecular mass: C 25 H 31 F 3 O 5 S 500.6<br />
Structural formula:<br />
HO<br />
COSCH 2 F<br />
CH 3 OCOC 2 H 5<br />
CH 3<br />
CH 3<br />
H<br />
O<br />
F<br />
F<br />
H<br />
Physicochemical properties:<br />
Description: Fluticasone propionate is a white to off-white powder. It is freely soluble<br />
in dimethyl sulfoxide and dimethylformamide, sparingly soluble in acetone,<br />
dichloromethane, ethyl acetate and chloroform, slightly soluble in methanol and 95%<br />
ethanol, and practically insoluble in water. Fluticasone propionate decomposes without<br />
melting. Onset of decomposition occurs at about 225°C.<br />
CLINICAL TRIALS<br />
Clinical Studies in Asthma<br />
There have been very rare reports of anxiety, sleep disorders and behavioural changes<br />
including hyperactivity and irritability (predominantly in children and adolescents).<br />
July 29, 2014<br />
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