Detecting Reporting Resistance in Fastidious Bacteria - SWACM
Detecting Reporting Resistance in Fastidious Bacteria - SWACM Detecting Reporting Resistance in Fastidious Bacteria - SWACM
Abiotrophia spp. / Granulicatella spp. (1) Nutritionally variant streptococci Requires 0.001% (1 µg/ml) pyridoxal hydrochloride – Add 5 µl of 20 µg/ml solution to 100 µl of drug in microdilution well (CAMHB + 2.5-5% LHB) May show decreased penicillin susceptibility… can cause difficulties in treating endocarditis – Combination therapy with penicillin or vancomycin plus aminoglycoside often prescribed…or 3 rd or 4 th generation cephalosporin – May require surgical intervention Many labs may not separate two genera – Genus identification not critical to guide therapy
Baddour et al. 2005. Circulation. 111:e394-434.
- Page 1 and 2: Detecting / Reporting Resistance in
- Page 3 and 4: CLSI M45-A2 Guideline Abiotrophia /
- Page 5 and 6: Organisms Included in CLSI M45-A2 M
- Page 7 and 8: Table 17. Summary of Testing Condit
- Page 9 and 10: Can we test M45-A2 organisms with a
- Page 12 and 13: Qualifying Results Optional Comment
- Page 16 and 17: CLSI M45-A2 Table 1 Abiotrophia / G
- Page 18 and 19: CLSI M45-A2 Table 1 Abiotrophia / G
- Page 20 and 21: “S” only breakpoint Abiotrophia
- Page 22 and 23: Specimen: Blood Diagnosis: Endocard
- Page 24 and 25: Coryneforms and Corynebacterium spp
- Page 26 and 27: Specimen: Bone marrow Diagnosis: Le
- Page 28 and 29: CLSI M45-A2 Table 13 Pasteurella sp
- Page 30 and 31: Why should we do -lactamase test on
- Page 32 and 33: -Lactamase Testing of M45 Bugs Reco
- Page 34 and 35: Specimen: Cerebrospinal fluid Diagn
- Page 36 and 37: Procedure used in some labs to expe
- Page 38 and 39: HACEK Group Haemophilus aphrophilus
- Page 40 and 41: Specimen: Blood Diagnosis: Endocard
- Page 42 and 43: Moraxella catarrhalis “If desired
- Page 44 and 45: Outcomes of Single Dose Azithromyci
- Page 46 and 47: Table 17. Summary of Testing Condit
- Page 48 and 49: Minimum Laboratory Requirements for
Abiotrophia spp. / Granulicatella spp. (1)<br />
Nutritionally variant streptococci<br />
Requires 0.001% (1 µg/ml) pyridoxal hydrochloride<br />
– Add 5 µl of 20 µg/ml solution to 100 µl of drug <strong>in</strong><br />
microdilution well (CAMHB + 2.5-5% LHB)<br />
May show decreased penicill<strong>in</strong> susceptibility… can<br />
cause difficulties <strong>in</strong> treat<strong>in</strong>g endocarditis<br />
– Comb<strong>in</strong>ation therapy with penicill<strong>in</strong> or vancomyc<strong>in</strong> plus<br />
am<strong>in</strong>oglycoside often prescribed…or 3 rd or 4 th generation<br />
cephalospor<strong>in</strong><br />
– May require surgical <strong>in</strong>tervention<br />
Many labs may not separate two genera<br />
– Genus identification not critical to guide therapy
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