Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
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Current Understanding of <strong>PNH</strong>:<br />
Chronic Haemolysis is the Underlying Cause of<br />
Progressive Morbidities and Mortality of <strong>PNH</strong><br />
Thrombosis<br />
Venous<br />
Arterial<br />
• PE/DVT<br />
• Stroke/TIA<br />
• Cerebral<br />
• MI<br />
• Dermal<br />
• Hepatic/Portal<br />
• Abdominal ischemia<br />
Fatigue / Impaired<br />
Quality of Life<br />
• Abdominal pain<br />
• Dysphagia<br />
• Poor physical functioning<br />
• Erectile dysfunction<br />
Chronic Kidney Disease<br />
• Renal insufficiency<br />
• Dialysis<br />
• Hypertension<br />
End Organ Damage<br />
• Brain<br />
• Liver<br />
• GI<br />
Pulmonary Hypertension<br />
• Dyspnoea<br />
• Cardiac Dysfunction<br />
Anaemia<br />
• Transfusions<br />
• Haemosiderosis<br />
1. International <strong>PNH</strong> Interest Group. Blood. 2005;106:3699-3709. 2. Brodsky R. <strong>Paroxysmal</strong> <strong>Nocturnal</strong> <strong>Haemoglobinuria</strong>. In: Hematology - Basic Principles<br />
and Practices. 4th ed. R Hoffman; EJ Benz;S Shattil et al, eds. Philadelphia, PA: Elsevier Churchill Livingstone; 2005; p. 419-427. 3. Hillmen P et al. N Engl J<br />
Med. 1995;333:1253-1258. 4. Rosse W et al. Hematology (Am Soc Hematol Educ Program). 2004:48-62. 5. Rother R et al. JAMA. 2005;293:1653-1662. 6.<br />
Socie G et al. Lancet. 1996;348:573-577. 7. Hill A et al. Br J Haematol. 2007;137:181-92. 8. Lee JW et al. Hematologica 2010. 95 (s2): Abstract #505 and<br />
506. 9. Hill A et al. Br J Haematol. 2010; May;149(3):414-25. 10. Hillmen P et al. Am. J. Hematol. 2010; 85:553–559.<br />
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