Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
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SOLIRIS ® Blocks Terminal Complement<br />
Complement Cascade<br />
SOLIRIS®<br />
C3<br />
C3a<br />
•<br />
SOLIRIS® binds with high affinity to C5<br />
Proximal<br />
C3b<br />
•<br />
Terminal complement - C5a and C5b-9<br />
activity blocked<br />
C5<br />
C5a<br />
•<br />
Proximal functions of complement<br />
remain intact<br />
Terminal<br />
C5b<br />
C5b-9<br />
Cause of Haemolysis<br />
in <strong>PNH</strong><br />
•<br />
Weak anaphylatoxin<br />
•<br />
Immune complex clearance<br />
•<br />
Microbial opsonization<br />
1. Figueroa JE, Densen P. Clin Microbiol Rev. 1991;4(3):359-395. 2. Walport MJ. N Engl J Med. 2001;344(14):1058-66. 3. SOLIRIS® (eculizumab) [package insert]. Alexion Pharmaceuticals; 2009. 4. Rother RP et al. Nature<br />
Biotech. 2007;25(11):1256-64.<br />
August 12_10_2010Gbl<br />
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