Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
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Thrombosis<br />
Chronic Kidney Disease<br />
Fatigue / / Impaired QOL<br />
Evidence of<br />
Pulmonary Hypertension in <strong>PNH</strong><br />
Pulmonary Hypertension<br />
Study 1:<br />
47% of patients (34/73) had elevated NT-proBNP<br />
≥160<br />
pg/ml, indicating PHT in these patients 1<br />
Study 2:<br />
43% of haemolytic <strong>PNH</strong> patients (12/28) had mild to<br />
moderate PHT and 7% (2/28) had severe PHT, measured<br />
by doppler echocardiography 2<br />
Study 3:<br />
80% of <strong>PNH</strong> patients with elevated BNP levels had<br />
reduced right ventricular ejection fraction (RVEF) 3<br />
1. Hill A et al. Blood. 2008;112 (11):Abstract 486. 2. Hill et al. Br J Haematol. 2006;133 (suppl 1):119:Abstract 316. 3. Hill et al. Blood. 2006;108(11): Abstract 979.<br />
August_12_2010Gbl<br />
22
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