Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Thrombosis<br />
Chronic Kidney Disease<br />
Fatigue / Impaired QOL<br />
Pulmonary Hypertension<br />
Fatigue and Quality of Life Conclusions<br />
• 96% of patients report fatigue 1<br />
– Fatigue/QoL independent of anemia/transfusion requirements<br />
• 76% of patients with <strong>PNH</strong> have disruptions in daily<br />
activities 1<br />
– 17% of patients were unemployed due to <strong>PNH</strong><br />
• Fatigue, QoL and abdominal pain are linked by<br />
underlying haemolysis and the threat of ischemia and<br />
mortality 2<br />
– 66% of patients report shortness of breath<br />
– 57% of patients report abdominal pain<br />
• 2.2-fold increased risk of mortality<br />
• 3.6-fold increased risk of developing TE<br />
• <strong>PNH</strong> symptoms are independent of clone size 3<br />
1. Meyers G et al. Blood. 2007;110(11):Abstract 3683. 2. Lee JW et al. Hematologica 2010. 95 (s2): Abstract #506. 3. Urbano-Ispizua A et<br />
al. Hematologica 2010. 95 (s2): Abstract #1022.<br />
August_12_2010Gbl<br />
20
Change language