Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...

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First Objective Describe the serious morbidities and mortality associated with chronic haemolysis in PNH patients August_12_2010Gbl 2
Paroxysmal Nocturnal Haemoglobinuria: A Chronic Disabling and Life-Threatening Disease • Estimated 4,000 – 6,000 patients in U.S. 1 • 5 year mortality: 35% 2 • Diagnosed at all Ages – Median age early 30’s 3,4 • Quality of life diminished 5 • Progressive disease 2-4 Patients Surviving (%) 100 80 60 40 20 0 Actuarial Survival From the Time of Diagnosis in 80 Patients With PNH 2 0 5 10 15 20 25 Years After Diagnosis Age- and sex- matched controls The expected survival of an age- and sex-matched control group is shown for comparison (Hillmen et al 1995). In a patient population where ½ the patients have
Page 1: Paroxysmal Nocturnal Haemoglobinuri
Page 5 and 6: The Defect in PNH The Somatic Mutat
Page 7 and 8: PNH is a Progressive Disease of Chr
Page 9 and 10: Thrombosis Chronic Kidney Disease F
Page 23 and 24: Common Symptoms of Haemolysis Signa
Page 25 and 26: Historical Management of PNH Bone M
Page 27 and 28: SOLIRIS ® Blocks Terminal Compleme
Page 29 and 30: Adverse Reactions Reported in ≥ 5
Page 31: August 12_10_2010Gbl Thank you Than

Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...

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