Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Thrombosis<br />
Chronic Kidney Disease<br />
Fatigue / Impaired QOL<br />
Haemolysis Causes Fatigue<br />
Independent of Anemia<br />
Pulmonary Hypertension<br />
• Rosse (Hoffman-Haematology) 1<br />
– “Many patients note a feeling of fatigue that may be<br />
disabling during periods of haemoglobinuria.”<br />
– This is not related to haemoglobin level (anaemia), as it<br />
disappears when the haemoglobinuria stops.”<br />
• Brodsky (Hoffman-Haematology) 2<br />
– “<strong>PNH</strong> patients frequently complain of disabling fatigue<br />
that is often out of proportion to the degree of anaemia.”<br />
• Multivariate analysis indicates haemolysis drives fatigue in<br />
<strong>PNH</strong> – not anaemia 3<br />
1. Rosse W. <strong>Paroxysmal</strong> nocturnal haemoglobinuria In: R Hoffman; EJ Benz; SJ Shattil et al., eds. Hematology: Basic Principles and Practice. 3rd ed. New<br />
York: Churchill-Livingstone; 2000:331-342. 2. Brodsky RA. <strong>Paroxysmal</strong> nocturnal haemoglobinuria. In: R Hoffman; EJ Benz; SJ Shattil et al., eds. Hematology.<br />
Basic Principles and Practice. 4th ed. Philadelphia: Elsevier Churchill Livingstone; 2005:419-427. 3. Hill A et al. Haematologica. 2008;93(s1):359. Abstract<br />
0903 and Presentation at: European Hematology Association 15 th Annual Meeting; June 15 th , 2008; Copenhagen, Denmark.<br />
August_12_2010Gbl<br />
18
Change language