Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...
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Thrombosis<br />
Chronic Kidney Disease<br />
Fatigue / Impaired QOL<br />
Thrombosis in <strong>PNH</strong><br />
Pulmonary Hypertension<br />
• 40-67% mortality in <strong>PNH</strong> results from thrombosis 1<br />
– Thrombosis is the leading cause of death in <strong>PNH</strong> 2<br />
– First TE increases risk for death 5 to 10-fold 1<br />
• DVT or PE most common clinical presentation 1<br />
• Arterial thromboses are also common 3<br />
– 39% of TE events occur at arterial sites<br />
• Clinical thrombosis evident in all <strong>PNH</strong> patients: 1<br />
– Minimal haemolysis<br />
– No transfusion history<br />
– Smaller clone size 3<br />
1. Hillmen P et al. Blood. 2007;110:12:4123-4128. 2. International <strong>PNH</strong> Group et al. Blood. 2005;106(12):3699-3709. 3. Lee JW et al. Hematologica 2010. 95<br />
(s2): Abstract #506. 4. Hall C et al. Blood. 2003;102:3587-3591.<br />
August_12_2010Gbl<br />
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