Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...

More documents

Recommendations

Info

Thrombosis Chronic Kidney Disease Fatigue / Impaired QOL Thrombosis in PNH Pulmonary Hypertension • Is the leading cause of death • Occurs in typical and atypical site • All patients with PNH are at risk for thrombosis August_12_2010Gbl 10
Thrombosis Chronic Kidney Disease Fatigue / Impaired QOL Pulmonary Hypertension Thrombosis in PNH: Common and Frequent Cause of Death • 40% of patients experience clinical thrombotic events 1 • Leading cause of death 2 – Accounts for 40–67% of deaths 1 – First thrombotic event can be fatal 1,3 – Median time to TE was 2.1-2.3 2.3 years from diagnosis 4 – First TE increases risk for death 5 to 10-fold 1 1. Hillmen et al. Blood 2007; 110: 4123-4128. 2. International PNH Group et al. Blood. 2005;106(12):3699-3709. 3. Audebert HJ et al. J Neurol. 2005;252:1379-1386. 4. De Latour. Blood. 2008; 112:3099-3106. August_12_2010Gbl 11
Page 1 and 2: Paroxysmal Nocturnal Haemoglobinuri
Page 3 and 4: Paroxysmal Nocturnal Haemoglobinuri
Page 5 and 6: The Defect in PNH The Somatic Mutat
Page 7 and 8: PNH is a Progressive Disease of Chr
Page 9: Thrombosis Chronic Kidney Disease F
Page 13 and 14: Thrombosis Chronic Kidney Disease F
Page 23 and 24: Common Symptoms of Haemolysis Signa
Page 25 and 26: Historical Management of PNH Bone M
Page 27 and 28: SOLIRIS ® Blocks Terminal Compleme
Page 29 and 30: Adverse Reactions Reported in ≥ 5
Page 31: August 12_10_2010Gbl Thank you Than

Paroxysmal Nocturnal Haemoglobinuria (PNH) Dr Conal McConville ...

Create successful ePaper yourself

Delete template?

Save as template?