Obesity & Lipodystrophy - Medical College of Wisconsin
Obesity & Lipodystrophy - Medical College of Wisconsin
Obesity & Lipodystrophy - Medical College of Wisconsin
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FPL: AKT2 gene<br />
(v-akt murine thymoma viral oncogene homolog 2)<br />
PI-dependent Ser-Thr protein kinase<br />
• R274H heterozygous<br />
mutation in a pedigree with<br />
lipodystrophy, DM and<br />
insulin resistance<br />
Courtesy <strong>of</strong> Stephen O’Rahilly<br />
George S, et al. Science 304; 1325-28, 2004<br />
Agarwal & Garg. Ann Rev Genomics Human Genet 7: 175-199, 2006.