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Obesity & Lipodystrophy - Medical College of Wisconsin

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Pathogenesis <strong>of</strong> lipodystrophy in FPLD<br />

patients<br />

• LMNA mutations induce nuclear<br />

dysfunction resulting in premature death<br />

or apoptosis <strong>of</strong> adipocytes<br />

• Why fat loss spares the face, neck and<br />

intra-abdominal region?

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