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Obesity & Lipodystrophy - Medical College of Wisconsin

Obesity & Lipodystrophy - Medical College of Wisconsin

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Lamin A/C Mutations in FPLD<br />

16kb<br />

2kb<br />

5' // // // 3'<br />

1 2 3 4 5 6 7 8 9 10 11 12<br />

R482Q<br />

* Cardiomyopathy<br />

† Emery-Dreifuss Muscular Dystrophy<br />

‡ Limb Girdle Muscular Dystrophy<br />

§ Mild Myopathy<br />

Mild <strong>Lipodystrophy</strong><br />

Cao and Hegele. Hum Mol Genet 9:109-112, 2002<br />

Garg A. N Engl J Med 350; 1220-34, 2004

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