Platelet Concentrates: A Promising Innovation In ... - Ssdctumkur.org

Platelet Concentrates
that initiate and support wound
healing.
Platelet
Concentrates:
Evolution:
In general, platelet
concentrates are blood derived
products used for the prevention
and treatment of hemorrhages due
to serious thrombopenia of the
central origin. The development of
platelet concentrates as bioactive
surgical additives that are applied
locally to promote wound healing
stems from the use of fibrin
adhesives. Since 1990, medical
science has recognized several
components in blood, which are a
part of the natural healing process;
when added to wounded tissues or
surgical sites, they have the
potential to accelerate healing.
Fibrin glue was originally described
in 1970 and is formed by
polymerizing fibrinogen with
thrombin and calcium. It was
originally prepared using donor
plasma; however, because of the
low concentration of fibrinogen in
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February 2011
plasma, the stability and quality of
fibrin glue were low 2 .
It is now well known that
platelets have many functions
beyond that of simple hemostasis.
Platelets contain important growth
factors that, when secreted, are
responsible for increasing cell
mitosis, increasing collagen
production, recruiting other cells to
the site of injury, initiating vascular
in-growth, and inducing cell
differentiation 3 .
The study of these growth
factors combined with the
discovery of their extrusion by
platelets has led to the
development of an autologus
platelet gel – PRP – to be used in
various surgical fields. Whitman et
al have called PRP an “autologus
alternative to fibrin glue”. Fibrin
glue obtained through blood bank
donations has been used for years
as hemostatic agent and surgical
adhesive. The important difference
in composition between PRP and
Fibrin Glue is the presence of a
high concentration of platelets and
51 Journal of Dental Sciences and Research