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Clinton - WGBH

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89.7 <strong>WGBH</strong>, Boston Public Radio<br />

<strong>WGBH</strong> Archives Bring Depth to Today’s Life Science Stories<br />

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By Phil Redo<br />

Managing Director, 89.7 <strong>WGBH</strong>, Boston Public Radio<br />

Almost five years ago, during a speech at the BIO 2007<br />

conference, Governor Deval Patrick announced the<br />

Massachusetts Life Sciences Initiative: a $1 billion<br />

investment package (over 10 years) to enhance and<br />

strengthen the state’s already internationally recognized<br />

leadership in the field.<br />

Life sciences is one of <strong>WGBH</strong> Radio’s editorial areas of concentration, and<br />

last fall listeners to <strong>WGBH</strong>’s Morning Edition heard an intriguing story reported<br />

by host Bob Seay.<br />

A young metabolic engineer, Jake Wintermute, and his colleagues at<br />

Harvard Medical School think they may have unlocked some important<br />

secrets about LSD, the notorious and illegal drug promoted in the 1960s by<br />

doctor/guru Timothy Leary.<br />

For more than 40 years, LSD and its close chemical relative, lysergic acid,<br />

have basically been under lock and key as controlled substances, and strictly<br />

regulated by both federal and state laws.<br />

Wintermute, who recently earned a PhD from Harvard Medical School<br />

in the Department of Systems Biology, has been researching pathways to<br />

new drugs these long-blacklisted compounds might yield. His interest is in<br />

lysergic acid, which can be made both cheaply and quickly using new bioengineering<br />

methods.<br />

The actual mechanism by which the compound works is still somewhat<br />

mysterious, Wintermute admitted, but said it has something to do with it<br />

What’s on 89.7 <strong>WGBH</strong><br />

Monday–Friday<br />

BBC World Update<br />

The Takeaway<br />

Morning Edition/Marketplace Morning<br />

The Xconomy Report (Fri)<br />

The Takeaway<br />

The Diane Rehm Show<br />

The Emily Rooney Show<br />

The Callie Crossley Show<br />

Fresh Air<br />

The World<br />

All Things Considered<br />

The World<br />

PBS NewsHour<br />

Jazz on <strong>WGBH</strong> with Eric Jackson/<br />

Jazz on <strong>WGBH</strong> with Steve Schwartz (Fri)<br />

Jazz with Bob Parlocha<br />

Saturday<br />

acting as a vasodilator: “It sort of opens up the blood vessels of the brain,<br />

improves the circulation in the brain; the sort of enhanced clarity that people<br />

on these drugs can sometimes benefit from comes from that.”<br />

While the technology is obviously critical, so is curiosity and, in this<br />

case, a dose of courage. “There are a lot of exciting new drugs that are being<br />

developed thanks to these new bioengineering technologies,” Wintermute<br />

told <strong>WGBH</strong>. “And no one yet has taken up lysergic acid as a kind of promising<br />

new precursor, and I think a lot of that is because there is this kind of stigma,<br />

taboo, when you are working on something that is so illegal or so close to<br />

illegal.”<br />

The potential benefits of such a new drug? Easing symptoms of Parkinson’s<br />

disease, a therapy for migraines and treatment for elder dementia.<br />

Drawing from<br />

materials in <strong>WGBH</strong>’s<br />

archives, Seay’s radio<br />

piece featured the<br />

opinions of the late<br />

Dr. Leary, who could be<br />

heard debating the<br />

benefits of LSD with<br />

Jerome Lettvin, an MIT<br />

professor, psychiatrist<br />

and cognitive scientist. Their exchange was lifted from a program that aired<br />

on <strong>WGBH</strong> television back in 1967. Far out!<br />

Watch the hour-long Lettvin-Leary debate online at<br />

openvault.wgbh.org/blog/2011/09/lsd-lettvin-vs-leary/<br />

Note: Schedule information accurate at press time; find the latest programming updates online at wgbh.org/radio<br />

Listen online at wgbh.org/listen, on your Internet radio, or on your HD radio at 89.7 HD1<br />

6am Living on Earth<br />

7am Innovation Hub<br />

8am Weekend Edition<br />

10am Studio 360<br />

11am This American Life<br />

12pm Says You!<br />

1pm Wait Wait…Don't Tell Me!<br />

2pm The Moth/Radio Lab<br />

3pm A Celtic Sojourn<br />

6pm A Prairie Home Companion<br />

8pm Says You!<br />

9pm Selected Shorts<br />

10pm JazzSet with Dee Dee Bridgewater<br />

11pm Jazz with Bob Parlocha<br />

6am<br />

7am<br />

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4pm<br />

5pm<br />

6pm<br />

7pm<br />

8pm<br />

10pm<br />

11pm<br />

12am<br />

Sunday<br />

On the Media<br />

Being<br />

Weekend Edition<br />

Bob Edwards Weekend<br />

Wait Wait…Don't Tell Me!<br />

A Prairie Home Companion<br />

Says You!<br />

America's Test Kitchen Radio<br />

Marketplace Money<br />

All Things Considered<br />

Humankind<br />

Jazz Decades<br />

Arts & Ideas<br />

Innovation Hub<br />

Eric’s Artist Spotlight<br />

Jazz with Bob Parlocha<br />

News programs on 89.7 <strong>WGBH</strong> are made possible by your contributions to the Independent Journalism Fund.<br />

24 Schedules, program info, playlists: wgbh.org/897<br />

The World Geo Quiz answer (see page 25): Ulcinj, Montenegro

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