Journal_1_2014_final_WEB

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12th Scientific Meeting of the Diabetic Foot Study Group of the EASD 12-14 September <strong>2014</strong> Bratislava, Slovakia Conference theme: Advancement of knowledge on all aspects of diabetic foot care Main subjects during conference: Epidemiology Basic and clinical science Diagnostics Classification Foot clinics Biomechanics, Osteoarthropathy Orthopaedic surgery Infection Revascularisation Uraemia Wound healing/outcome www.dfsg.org cells is distinctly different from normal dermal tissue, and because cell function and tissue performance is largely dependent on the cellular microenvironment, the healing process is trapped in a vicious circle. Ideally, tissue engineering could play an important role in the development of a scaffold that is able to guide the stem cells into the proper phenotype. Although various preclinical (animal) studies have been performed and show promising results, translation into clinical trials remains limited (reviewed in 22 ). Future perspectives Despite the substantial progress in skin tissue engineering over the past several decades, the regeneration of fully functional skin following a burn wound still has not been achieved. Elucidating the signals that are required to guide the cells into the desired phenotype and away from the myofibroblast phenotype will be useful for scaffold design. Such scaffolds should create the microenvironment necessary for skin regeneration instead of scar formation. In addition to the aesthetic problems and functional impairments due to diminished joint mobility of scars, other problems may occur from scarring as a result of the absence of skin appendages. For example, the lack of sweat glands may impair the thermoregulatory function of the skin. In addition, scars often lack hair follicles and sebaceous glands. Hair transplantation and skin expansion techniques have been used to restore the lack of hair follicles in scars 23, 24 . In vitro and in vivo experiments have shown that a tissue engineering approach may be successful to reconstitute hair follicles 25 . The use of stem cells in skin substitutes have also shown promising results with respect to hair follicle induction 26 . Further research to elucidate the mechanisms involved in the development of sebaceous glands and sweat glands is needed to address the lack of these structures in the healing wound. m 20. Jurgens WJ, Oedayrajsingh-Varma MJ, Helder MN, Zandiehdoulabi B, Schouten TE, Kuik DJ, et al. Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies. Cell Tissue Res. 2008;332(3):415-26. 21. van der Veen VC, Vlig M, van Milligen FJ, de Vries SI, Middelkoop E, Ulrich MM. Stem Cells in Burn Eschar. Cell Transplant. 2012. Epub 2011/09/29. 22. Jackson WM, Nesti LJ, Tuan RS. Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem cells translational medicine. 2012;1(1):44-50. 23. Oh SJ, Koh SH, Lee JW, Jang YC. Expanded flap and hair follicle transplantation for reconstruction of postburn scalp alopecia. JCraniofacSurg. 2010;21(6):1737-40. 24. Gho CG, Martino Neumann HA. Donor hair follicle preservation by partial follicular unit extraction. A method to optimize hair transplantation. JDermatologTreat. 2010;21(6):337-49. 25. Sriwiriyanont P, Lynch KA, McFarland KL, Supp DM, Boyce ST. Characterization of hair follicle development in engineered skin substitutes. PLoSOne. 2013;8(6):e65664. 26. Liang X, Ding Y, Zhang Y, Tse HF, Lian Q. Paracrine mechanisms of Mesenchymal Stem cell-based therapy: Current status and perspectives. Cell Transplant. 2013.
EWMA <strong>2014</strong> MADRID VISIT US AT BOOTH N° 10B06 Flaminal ® Your peace of mind Flaminal ® , a total approach for every wound and a convenient solution for you and your patient. SYMPOSIUM on multidisciplinary wound care: HOW TO INCREASE your added value as a wound care nurse? 15.05.14 from 15:40-16:40 in room N105/106 www.flenpharma.com I info@flenpharma.com
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Now available - DURAFIBER Ag with a
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EWMA n GNEAUPP 2014 Christina Lindh
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will be held at this year’s EWMA
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Submit your next paper to Phlebolog
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Nordic Diabetic Foot Symposium 2014
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Programme in Austria 25th Conferenc
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JOURNAL CITATION REPORTS 2013 SPECI
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EWMA Managing Wounds as a Team - Ex
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