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biotherapie : revolution therapeutique en rhumatologie - sofomec

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BIOTHERAPIE : REVOLUTION<br />

THERAPEUTIQUE EN<br />

RHUMATOLOGIE<br />

Modeste KOUMOUVI<br />

Rhumatologie CHG Carcassonne


CAS CLINIQUE<br />

Fév. 2000, Anne-Laure D…, 8 ans<br />

Arthrite juvénile : 3 ans, MTX<br />

Impot<strong>en</strong>ce, RM : 4 heures<br />

NAG : 16, NAD : 14<br />

CRP: 112 VS : 80 mm<br />

Scolarité compromise<br />

12 fév : 1ere inj Etanercept (Enbrel)<br />

16 fév : 2ème inj Etanercept<br />

20 fév : vélo


Professor Sir<br />

Ravinder Maini,<br />

Pr Marc FELDMANN<br />

K<strong>en</strong>nedy Research Institute at Imperial<br />

College London. He led a team of<br />

researchers over a 15-year period looking<br />

for new treatm<strong>en</strong>ts for rheumatoid arthritis.


Physiopathologie de la PR<br />

CTLA4 Ig : Abatacept (Or<strong>en</strong>cia)<br />

antiCD20 : Rituximab<br />

AntiTNF : Etanercept (Enbrel)<br />

Adalimumab (Humira<br />

Infliximab (Rémicade


LES ANTI-TNF


ANTI-IL1


ANTI-CD20<br />

(Anti-Lymphocytes B)


Anti-lymphocytes T

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