PD Dr. med. Holger HänÃle
PD Dr. med. Holger HänÃle
PD Dr. med. Holger HänÃle
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<strong>PD</strong> <strong>Dr</strong>. <strong>med</strong>. <strong>Holger</strong> Hänßle<br />
Klinische Tätigkeit:<br />
Allgemeine Ambulanz<br />
Ambulante Operationen<br />
Pigmentmalsprechstunde<br />
Dermatologische Onkologie und Tumornachsorge-Sprechstunde<br />
Sonographie der Haut und der regionalen Lymphknoten<br />
Phlebologie<br />
Lasersprechstunde<br />
Forschungsschwerpunkte:<br />
Melanomfrüherkennung und (digitale) Dermatoskopie<br />
(Immun-)Therapie des malignen Melanoms<br />
Ultraschalldiagnostik<br />
Genodermatosen (Verhornungsstörungen)<br />
Forschungsförderungen: Niedersächsische Krebsgesellschaft, Bundesministerium für<br />
Wirtschaft und Technologie (ZIM-Projekt), Industrie<br />
Ausgewählte Publikationen:<br />
Melanomfrüherkennung und (digitale) Dermatoskopie<br />
Haenssle H.A., Richter A., Buhl T., Haas E., Holzkamp R., Emmert S., Schön M.P.: Pigmented basal<br />
cell carcinomas 15 years after orbital radiation therapy for Graves ophthalmopathy. Archives of<br />
Dermatology, 2011; 147(4):511-2.<br />
Buhl T., Haenssle H.A.: Symmetrically enlarging pigmented lesion in an adolescent. Hautarzt, 2011;<br />
62(8):625-6.<br />
Buhl T., Hansen-Hagge C., Korpas B., Kaune K.M., Haas E., Rosenberger A., Schön M.P., Emmert<br />
S., Haenssle H.A.: Integrating static and dynamic features of melanoma: The DynaMel algorithm.<br />
Journal of the American Academy of Dermatology, 2011 Jun 7. [Epub ahead of print]<br />
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Johnsen S., Rosenberger A.,<br />
Schön M.P., Emmert S.: Selection of patients for long-term surveillance with digital dermoscopy by<br />
assessment of melanoma risk factors. Archives of Dermatology, 2010; 146(3):257-64.<br />
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Rosenberger A., Krueger U.,<br />
Schön M.P., Emmert S.: Seven-point checklist for dermatoscopy: performance during 10 years of<br />
prospective surveillance of patients at increased melanoma risk. Journal of the American Academy<br />
of Dermatology, 2010; 62(5):785-93.<br />
Haenssle H.A., Kaune K.M., Buhl T., Thoms K.M., Padeken M., Emmert S., Schön M.P.: Melanoma<br />
arising in segmental nevus spilus: detection by sequential digital dermatoscopy. Journal of the<br />
American Academy of Dermatology, 2009; 61(2):337-41.<br />
Haenssle H.A., Kaune K.M., Buhl T., Thoms KM., Padeken M., Mitteldorf C., Emmert S.: Large<br />
speckled lentiginous nevus superimposed with Spitz nevi: Sequential digital dermoscopy may lead to<br />
unnecessary excisions triggered by dynamic changes. Clinical and Experimental Dermatology,<br />
2009; 34(2):212-5.<br />
Haenssle H.A.: Strategien zur klinischen Früherkennung des malignen Melanoms -Gegenwart und<br />
Zukunft. TumorDiagnostik und Therapie, 2009; Ausg. 6, Jahrg. 30: 302-306.<br />
Haenssle H.A.: Melanomfrüherkennung durch sequentielle digitale Dermatoskopie,<br />
Dermatologie, 2009; 35:75–78.<br />
Aktuelle<br />
Haenssle H.A.: Blickdiagnostik: Pigmentmale, Via Medici, Heft 03/2007:62-64
Haenssle H.A., Krueger U., Vente C., Thoms KM., Bertsch HP., Zutt M., Rosenberger A., Neumann<br />
C., Emmert S.: Results from an observational trial: digital epiluminescence microscopy follow-up of<br />
atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in<br />
detecting melanoma. Journal of Investigative Dermatology, 2006; 126(5):980-5.<br />
Haenssle H.A., Vente C., Bertsch H.P., Rupprecht R., Abuzahra F., Junghans V., Ellinghaus B.,<br />
Emmert S., Hallermann C., Neumann Ch.: Results of a surveillance programme for patients at high<br />
risk for malignant melanoma using digital and conventional dermoscopy. European Journal for<br />
Cancer Prevention, 2004; 13(2):133-8.<br />
(Immun-)Therapie des malignen Melanoms<br />
Haenssle H.A., Riedl P., Buhl T., Schardt A., Rosenberger A., Schön M.P., Schirmbeck R.:<br />
Intracellular delivery of MHC class I-binding epitopes: Dendritic cells loaded and matured with cationic<br />
peptide/poly(I:C) complexes efficiently activate T cells. Experimental Dermatology, 2010; 19(1):19-<br />
28.<br />
Knudsen S., Schardt A., Buhl T., Boeckmann L., Schön M.P., Neumann C., Haenssle H.A.: Enhanced<br />
T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma<br />
cells. Experimental Dermatology, 2010; 19(2):108-16.<br />
Haenssle H.A., Buhl T., Knudsen S., Krueger U., Reich K., Neumann C.: CD40 ligation during<br />
dendritic cell maturation reduces cell death and prevents interleukin-10-induced regression to<br />
macrophagelike monocytes. Experimental Dermatology, 2008; 17(3):177-87.<br />
Kretschmer L., Thoms K.M., Peeters S., Haenssle H.A., Bertsch H.P., Emmert S.: Postoperative<br />
morbidity of lymph node excision for cutaneous melanoma-sentinel lymphonodectomy versus<br />
complete regional lymphnode dissection. Melanoma Research, 2008; 18(1):16-21.<br />
Haenssle H.A.: Vaccination therapy with tumor-dendritic cell hybrids: a promising therapeutic<br />
approach? Current Opinion in Investigational <strong>Dr</strong>ugs, 2005; 6(12): 1240-5. Review.<br />
Kretschmer L., Beckmann I., Thoms K.M., Haenssle H.A., Bertsch H.P., Neumann Ch.: Sentinel<br />
lymphonodectomy does not increase the risk of loco-regional cutaneous metastases of malignant<br />
melanomas. European Journal of Cancer, 2005; 41(4):531-8.<br />
Haenssle H.A., Emmert S., Krause S.W., Zutt M., Kretschmer L., Schmidberger H., Andreesen R.,<br />
Soruri A.: Hybrid cell vaccination in metastatic melanoma: Results of a phase I/II study. Journal of<br />
Immunotherapy, 2004; 27(2):147-55.<br />
Emmert S., Zutt M., Haenssle H.A., Neumann C., Kretschmer L.: Inefficacy of vindesine monotherapy<br />
in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic<br />
agents. Melanoma Research, 2003; 13(3):299-302.<br />
Genodermatosen (Verhornungsstörungen)<br />
Haenssle H.A., Finkenrath A., Hausser I., Oji V., Traupe H., Hennies HC., Neumann C., Emmert S.:<br />
Effective treatment of severe thermodysregulation by oral retinoids in a patient with recessive<br />
congenital lamellar ichthyosis. Clinical and Experimental Dermatology, 2008; 33(5):578-81.<br />
Emmert S., Küster W., Hennies HC., Zutt M., Haenssle H.A., Kretschmer L., and Neumann C.: 47<br />
patients in 14 families with the rare genodermatosis keratosis punctata palmoplantaris Buschke-<br />
Fischer-Brauer. European Journal of Dermatology, 2003; 13:16-20.<br />
Emmert S., Küster W., Zutt M., Hänssle H.A., Hallermann C., Kretschmer L., and Neumann C.: A new<br />
family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer.<br />
Journal of the American Academy of Dermatology, 2003; 49:1166-1169.
<strong>Holger</strong> Haenssle, MD<br />
Clinical spectrum:<br />
General Dermatology (outpatient clinic)<br />
Outpatient Surgery<br />
Pigmented Lesion Clinic (dermatoscopy)<br />
Dermatooncology Clinic and Tumor Follow-up Clinic<br />
Ultrasound examination of skin/subcutaneous tissue<br />
Phlebology<br />
Laser Surgery Clinic<br />
Scientific profile:<br />
Early detection of melanoma and (digital) Dermatoscopy<br />
(Immuno-)Therapy of metastasized melanoma<br />
Diagnostic use of Ultrasound<br />
Genodermatoses<br />
Funding: Niedersächsische Krebsgesellschaft, Bundesministerium für<br />
Wirtschaft und Technologie (ZIM-Project), Industry<br />
Selected Publications:<br />
Early detection of melanoma and (digital) Dermatoscopy<br />
Haenssle H.A., Richter A., Buhl T., Haas E., Holzkamp R., Emmert S., Schön M.P.: Pigmented basal<br />
cell carcinomas 15 years after orbital radiation therapy for Graves ophthalmopathy. Archives of<br />
Dermatology, 2011; 147(4):511-2.<br />
Buhl T., Haenssle H.A.: Symmetrically enlarging pigmented lesion in an adolescent. Hautarzt, 2011;<br />
62(8):625-6.<br />
Buhl T., Hansen-Hagge C., Korpas B., Kaune K.M., Haas E., Rosenberger A., Schön M.P., Emmert<br />
S., Haenssle H.A.: Integrating static and dynamic features of melanoma: The DynaMel algorithm.<br />
Journal of the American Academy of Dermatology, 2011 Jun 7. [Epub ahead of print]<br />
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Johnsen S., Rosenberger A.,<br />
Schön M.P., Emmert S.: Selection of patients for long-term surveillance with digital dermoscopy by<br />
assessment of melanoma risk factors. Archives of Dermatology, 2010; 146(3):257-64.<br />
Haenssle H.A., Korpas B., Hansen-Hagge C., Buhl T., Kaune K.M., Rosenberger A., Krueger U.,<br />
Schön M.P., Emmert S.: Seven-point checklist for dermatoscopy: performance during 10 years of<br />
prospective surveillance of patients at increased melanoma risk. Journal of the American Academy<br />
of Dermatology, 2010; 62(5):785-93.<br />
Haenssle H.A., Kaune K.M., Buhl T., Thoms K.M., Padeken M., Emmert S., Schön M.P.: Melanoma<br />
arising in segmental nevus spilus: detection by sequential digital dermatoscopy. Journal of the<br />
American Academy of Dermatology, 2009; 61(2):337-41.<br />
Haenssle H.A., Kaune K.M., Buhl T., Thoms KM., Padeken M., Mitteldorf C., Emmert S.: Large<br />
speckled lentiginous nevus superimposed with Spitz nevi: Sequential digital dermoscopy may lead to<br />
unnecessary excisions triggered by dynamic changes. Clinical and Experimental Dermatology,<br />
2009; 34(2):212-5.<br />
Haenssle H.A.: Strategien zur klinischen Früherkennung des malignen Melanoms -Gegenwart und<br />
Zukunft. TumorDiagnostik und Therapie, 2009; Ausg. 6, Jahrg. 30: 302-306.<br />
Haenssle H.A.: Melanomfrüherkennung durch sequentielle digitale Dermatoskopie,<br />
Dermatologie, 2009; 35:75–78.<br />
Aktuelle<br />
Haenssle H.A.: Blickdiagnostik: Pigmentmale, Via Medici, Heft 03/2007:62-64
Haenssle H.A., Krueger U., Vente C., Thoms KM., Bertsch HP., Zutt M., Rosenberger A., Neumann<br />
C., Emmert S.: Results from an observational trial: digital epiluminescence microscopy follow-up of<br />
atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in<br />
detecting melanoma. Journal of Investigative Dermatology, 2006; 126(5):980-5.<br />
Haenssle H.A., Vente C., Bertsch H.P., Rupprecht R., Abuzahra F., Junghans V., Ellinghaus B.,<br />
Emmert S., Hallermann C., Neumann Ch.: Results of a surveillance programme for patients at high<br />
risk for malignant melanoma using digital and conventional dermoscopy. European Journal for<br />
Cancer Prevention, 2004; 13(2):133-8.<br />
(Immuno-)Therapy of metastasized Melanoma<br />
Haenssle H.A., Riedl P., Buhl T., Schardt A., Rosenberger A., Schön M.P., Schirmbeck R.:<br />
Intracellular delivery of MHC class I-binding epitopes: Dendritic cells loaded and matured with cationic<br />
peptide/poly(I:C) complexes efficiently activate T cells. Experimental Dermatology, 2010; 19(1):19-<br />
28.<br />
Knudsen S., Schardt A., Buhl T., Boeckmann L., Schön M.P., Neumann C., Haenssle H.A.: Enhanced<br />
T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma<br />
cells. Experimental Dermatology, 2010; 19(2):108-16.<br />
Haenssle H.A., Buhl T., Knudsen S., Krueger U., Reich K., Neumann C.: CD40 ligation during<br />
dendritic cell maturation reduces cell death and prevents interleukin-10-induced regression to<br />
macrophagelike monocytes. Experimental Dermatology, 2008; 17(3):177-87.<br />
Kretschmer L., Thoms K.M., Peeters S., Haenssle H.A., Bertsch H.P., Emmert S.: Postoperative<br />
morbidity of lymph node excision for cutaneous melanoma-sentinel lymphonodectomy versus<br />
complete regional lymphnode dissection. Melanoma Research, 2008; 18(1):16-21.<br />
Haenssle H.A.: Vaccination therapy with tumor-dendritic cell hybrids: a promising therapeutic<br />
approach? Current Opinion in Investigational <strong>Dr</strong>ugs, 2005; 6(12): 1240-5. Review.<br />
Kretschmer L., Beckmann I., Thoms K.M., Haenssle H.A., Bertsch H.P., Neumann Ch.: Sentinel<br />
lymphonodectomy does not increase the risk of loco-regional cutaneous metastases of malignant<br />
melanomas. European Journal of Cancer, 2005; 41(4):531-8.<br />
Haenssle H.A., Emmert S., Krause S.W., Zutt M., Kretschmer L., Schmidberger H., Andreesen R.,<br />
Soruri A.: Hybrid cell vaccination in metastatic melanoma: Results of a phase I/II study. Journal of<br />
Immunotherapy, 2004; 27(2):147-55.<br />
Emmert S., Zutt M., Haenssle H.A., Neumann C., Kretschmer L.: Inefficacy of vindesine monotherapy<br />
in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic<br />
agents. Melanoma Research, 2003; 13(3):299-302.<br />
Genodermatoses<br />
Haenssle H.A., Finkenrath A., Hausser I., Oji V., Traupe H., Hennies HC., Neumann C., Emmert S.:<br />
Effective treatment of severe thermodysregulation by oral retinoids in a patient with recessive<br />
congenital lamellar ichthyosis. Clinical and Experimental Dermatology, 2008; 33(5):578-81.<br />
Emmert S., Küster W., Hennies HC., Zutt M., Haenssle H.A., Kretschmer L., and Neumann C.: 47<br />
patients in 14 families with the rare genodermatosis keratosis punctata palmoplantaris Buschke-<br />
Fischer-Brauer. European Journal of Dermatology, 2003; 13:16-20.<br />
Emmert S., Küster W., Zutt M., Hänssle H.A., Hallermann C., Kretschmer L., and Neumann C.: A new<br />
family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer.<br />
Journal of the American Academy of Dermatology, 2003; 49:1166-1169.