Program and the Book of Abstracts (PDF) - Mrs-serbia.org.rs

Tenth Young Researchers Conference – Materials Science and Engineering
December 21-23, 2011, Hall 2, SASA, Knez Mihailova 35 & 36, Belgrade, Serbia
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Investigation on the potential application of thermosensitive hydrogels
for controlled release of phenacetin
Snežana Ilić-Stojanović 1 , Ljubiša Nikolić 1 , Vesna Nikolić 1 ,
Mihajlo Stanković 1 , Slobodan Petrović 2 , Jela Milić 3
1 University of Niš, Faculty of Technology, Leskovac, Serbia, 2 University of Belgrade, Faculty of
Technology and Metallurgy, Belgrade, Serbia, 3 University of Belgrade, Faculty of Pharmacy,
Belgrade, Serbia
Many scientific researches over the past few years have been focused on hydrogels containing
N-isopropylacrylamide (NIPAM) as monomer. NIPAM based hydrogels with 20 mol. % 2-
hydroxypropylmethacrylate (HPMet), p(NIPAM-HPMet), were synthesized using a variety of the
molar ratios of crosslinker ethylene glycol dimethacrylate (EGDMA), also their characterization
was performed. FTIR spectrum of xerogel indicates the performed synthesis by the initiation of
radicals. SEM micrographs show the porous surfaces of xerogels. Potential applications of
synthesized hydrogels as drug carriers for controlled release were investigated by HPLC method.
The results show that the thermosensitive p(NIPAM-HPMet) hydrogel with 1 mol.% EGDMA has
the highest porosity, exhibits the highest degree of swelling at 20 °C and releases the largest amount
phenacetin (0.043mg/cm 3 ) at 40 °C.
The financial support of the Ministry of Education and Science, Republic of Serbia (the project
TR 34012) is gratefully acknowledged.
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Production and characterization of hydrogel nanocomposites based on alginate
and poly(vinyl alcohol) with incorporated silver nanoparticles
Milena Nemet, Jasmina Stojkovska, Željka Jovanović,
Vesna Mišković-Stanković, Bojana Obradović
Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia
Nanocomposite hydrogels with incorporated silver nanoparticles (AgNPs) provide variety of
potential applications as antimicrobial agents in fields ranging from biomedicine and pharmacy to
environmental engineering. In this work, we have combined electrochemical synthesis of AgNPs in
alginate solution and different gelation methods (ion exchange, freezing-thawing) in order to
produce nanocomposite hydrogels based on alginate and poly(vinyl alcohol) (PVA) in different
forms (discs, beads, microbeads). The novel nanocomposites were characterized regarding
biomechanical properties in a biomimetic bioreactor and antimicrobial activity against Escherichia
coli. The results have shown potentials of the novel technique for production of different
nanocomposite hydrogels with controlled properties.
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