Lasers and photothermal therapy
Lasers and photothermal therapy
Lasers and photothermal therapy
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Exogenous photosensitizers<br />
Cu(II)-hematoporphyrin<br />
CuHp<br />
λ ε max = 400 nm; 500-550 nm<br />
Amelanotic melanoma B78H1 cells in vitro<br />
CuHp 3-26 µM for 3, 6, 9, 14, 18 h<br />
532 nm Q-switched Nd:YAG laser, 10 ns, >50mJ·pulse -1 , 10 Hz<br />
treated (CuHp + pulsed laser)<br />
treated (CuHp + CW laser)<br />
50% cell survival for t > 120 s<br />
no cell killing, t = 40 min.<br />
M.Soncin et al. (1999) Photochem. Photobiol. 69, 708-712.
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