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Lasers and photothermal therapy

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Exogenous photosensitizers<br />

Pd-octabutoxy-naphthalocyanine<br />

PdNc(Obu) 8<br />

λ ε max = 827 nm<br />

BALB/c mice EMT6 tumour<br />

PdNc 0.6 ± 0.1 mg·kg -1 i.p. for 0-305 h<br />

Pharmacokinetics measured<br />

highest tumour / normal skin ratio<br />

highest tumour / muscle ratio<br />

~ 12 at 48-175 h<br />

20 ± 9 at 48-175 h<br />

M.Bucking et al. (2000) J.Photochem. Photobiol. B:Biol. 58, 87-93.

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