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Lasers and photothermal therapy

Lasers and photothermal therapy

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Photothermal damage<br />

Modifications induced by the photothermic process<br />

Temperature<br />

43-45°C<br />

Histological modifications<br />

Conformational changes, shrinkage, hyperthermia (cell death)<br />

50°C Reduction of enzymatic activity<br />

60°C<br />

Denaturation of the proteins, coagulation of the collagens,<br />

membrane permeabilisation<br />

100°C Formation of extracellular vacuoles<br />

> 100°C Breaking of the vacuoles, carbonisation<br />

300-1000°C<br />

Thermoablation of the tissue<br />

60-100 o C<br />

> 300 o C<br />

3350°C Vaporisation of carbon<br />

37-45 o C<br />

100-300 o C<br />

J.-L.Boulnois (1986) <strong>Lasers</strong> Med. Sci. 1, 47-66.<br />

S.Thomsen (1991) Photochem. Photobiol. 53, 825-835.

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