Lasers and photothermal therapy
Lasers and photothermal therapy
Lasers and photothermal therapy
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Photothermal damage<br />
Modifications induced by the photothermic process<br />
Temperature<br />
43-45°C<br />
Histological modifications<br />
Conformational changes, shrinkage, hyperthermia (cell death)<br />
50°C Reduction of enzymatic activity<br />
60°C<br />
Denaturation of the proteins, coagulation of the collagens,<br />
membrane permeabilisation<br />
100°C Formation of extracellular vacuoles<br />
> 100°C Breaking of the vacuoles, carbonisation<br />
300-1000°C<br />
Thermoablation of the tissue<br />
60-100 o C<br />
> 300 o C<br />
3350°C Vaporisation of carbon<br />
37-45 o C<br />
100-300 o C<br />
J.-L.Boulnois (1986) <strong>Lasers</strong> Med. Sci. 1, 47-66.<br />
S.Thomsen (1991) Photochem. Photobiol. 53, 825-835.