Lasers and photothermal therapy

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Photothermal damage Thermal tissue damage 100 s 1 s 54 o C 68 o C A.Katzir (1993) Lasers and Optical Fibers in Medicine. P.Rol et al. (2000) Graefe’s Arch. Clin. Exp. Ophthalmol. 238, 249-272.
Photothermal damage Modifications induced by the photothermic process Temperature 43-45°C Histological modifications Conformational changes, shrinkage, hyperthermia (cell death) 50°C Reduction of enzymatic activity 60°C Denaturation of the proteins, coagulation of the collagens, membrane permeabilisation 100°C Formation of extracellular vacuoles > 100°C Breaking of the vacuoles, carbonisation 300-1000°C Thermoablation of the tissue 60-100 o C > 300 o C 3350°C Vaporisation of carbon 37-45 o C 100-300 o C J.-L.Boulnois (1986) Lasers Med. Sci. 1, 47-66. S.Thomsen (1991) Photochem. Photobiol. 53, 825-835.
Page 1 and 2: Lasers and Photothermal Therapy Pet
Page 3 and 4: Photodynamic therapy (PDT) Energy t
Page 5 and 6: Photothermal Therapy ϕωζ , ϕω
Page 7 and 8: Photosensitizers - Low toxicity - A
Page 9 and 10: Background Pulsed mode -10 -3 ÷ 10
Page 11 and 12: Light-tissue tissue interaction Abs
Page 13 and 14: Light-tissue tissue interaction Ref
Page 15 and 16: Light-tissue tissue interaction A.K
Page 17 and 18: Light-tissue tissue interaction W·
Page 19 and 20: Photothermal damage Thermal paramet
Page 21 and 22: Photothermal damage Thermal paramet
Page 23 and 24: Photothermal damage Single pulse of
Page 25 and 26: Photothermal damage Pulses with rep
Page 27: Photothermal damage Tissue damage f
Page 31 and 32: Photothermal damage R.R.Anderson an
Page 33 and 34: Excimer Ar Ruby Alexandrite Dye Dio
Page 35 and 36: Endogenous photosensitizers Melanin
Page 37 and 38: Hair Removal Selective Absorption i
Page 39 and 40: Endogenous photosensitizers Hemoglo
Page 41 and 42: Laser treatment of port wine stains
Page 43 and 44: Endogenous photosensitizers Collage
Page 45 and 46: Photothermal therapy in Ophthalmolo
Page 47 and 48: Exogenous photosensitizers Porphyri
Page 49 and 50: Exogenous photosensitizers Ni-octab
Page 51 and 52: Exogenous photosensitizers Cu(II)-h
Page 53 and 54: Conclusions Photothermal laser ther
Page 55: Thank you !

Lasers and photothermal therapy

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