Lasers and photothermal therapy
Lasers and photothermal therapy Lasers and photothermal therapy
Photothermal damage Selective photothermolysis (SP) confined damage to the specific tissue structures by regulating pulse duration and repetition rate target 0.1 1-10 100 1000 µm pulse 10 -9 10 -6 10 -3 10 -1 s R.R.Anderson and J.A.Parish (1983) Science 220, 524-527.
Photothermal damage Tissue damage function 63% damage at Ω = 1 ∆E ≈ 290-630 kJ·mol -1 F.C.Henriques, 1947 Ω = A τ denat e − ∆ E RT R.Birngruber, 1985 t pulse ≥τ denat A.Katzir (1993) Lasers and Optical Fibers in Medicine. P.Rol et al. (2000) Graefe’s Arch. Clin. Exp. Ophthalmol. 238, 249-272.
- Page 1 and 2: Lasers and Photothermal Therapy Pet
- Page 3 and 4: Photodynamic therapy (PDT) Energy t
- Page 5 and 6: Photothermal Therapy ϕωζ , ϕω
- Page 7 and 8: Photosensitizers - Low toxicity - A
- Page 9 and 10: Background Pulsed mode -10 -3 ÷ 10
- Page 11 and 12: Light-tissue tissue interaction Abs
- Page 13 and 14: Light-tissue tissue interaction Ref
- Page 15 and 16: Light-tissue tissue interaction A.K
- Page 17 and 18: Light-tissue tissue interaction W·
- Page 19 and 20: Photothermal damage Thermal paramet
- Page 21 and 22: Photothermal damage Thermal paramet
- Page 23 and 24: Photothermal damage Single pulse of
- Page 25: Photothermal damage Pulses with rep
- Page 29 and 30: Photothermal damage Modifications i
- Page 31 and 32: Photothermal damage R.R.Anderson an
- Page 33 and 34: Excimer Ar Ruby Alexandrite Dye Dio
- Page 35 and 36: Endogenous photosensitizers Melanin
- Page 37 and 38: Hair Removal Selective Absorption i
- Page 39 and 40: Endogenous photosensitizers Hemoglo
- Page 41 and 42: Laser treatment of port wine stains
- Page 43 and 44: Endogenous photosensitizers Collage
- Page 45 and 46: Photothermal therapy in Ophthalmolo
- Page 47 and 48: Exogenous photosensitizers Porphyri
- Page 49 and 50: Exogenous photosensitizers Ni-octab
- Page 51 and 52: Exogenous photosensitizers Cu(II)-h
- Page 53 and 54: Conclusions Photothermal laser ther
- Page 55: Thank you !
Photothermal damage<br />
Tissue damage function<br />
63% damage at Ω = 1<br />
∆E ≈ 290-630 kJ·mol -1<br />
F.C.Henriques, 1947<br />
Ω<br />
=<br />
A<br />
τ<br />
denat<br />
e<br />
−<br />
∆ E<br />
RT<br />
R.Birngruber, 1985<br />
t pulse ≥τ denat<br />
A.Katzir (1993) <strong>Lasers</strong> <strong>and</strong> Optical Fibers in Medicine.<br />
P.Rol et al. (2000) Graefe’s Arch. Clin. Exp. Ophthalmol. 238, 249-272.
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