ABCD ABCD - Molecular Devices
ABCD ABCD - Molecular Devices
ABCD ABCD - Molecular Devices
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Quality control software: batch statistics<br />
<strong>ABCD</strong><br />
200%CTL: full activation of GPCR X1 by reference agonist<br />
100%CTL: no activation of GPCR X1 using buffer<br />
Ralf Heilker<br />
Dep. of Integrated Lead Discovery<br />
Primary screen<br />
<strong>ABCD</strong><br />
100 % CTL: inactive compound<br />
200 % CTL: reference agonist stimulated<br />
Hit threshold<br />
• ~750.000 compounds<br />
• Hit threshold >150 %CTL<br />
• ~23000 primary hits (hit rate of 3.1 %)<br />
Ralf Heilker<br />
Dep. of Integrated Lead Discovery
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