ABCD ABCD - Molecular Devices
ABCD ABCD - Molecular Devices
ABCD ABCD - Molecular Devices
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Selectivity profile of "potent and efficient"<br />
GPCR X1 hits vs GPCR X2/X3<br />
<strong>ABCD</strong><br />
EC 50 (X1) [µM]<br />
No Effect on Subtype<br />
X2<br />
No Effect on<br />
Subtype X3<br />
Selectivity_X2<br />
Selectivity_X3<br />
No Effect on Subtypes X2<br />
or X3<br />
Ralf Heilker<br />
Dep. of Integrated Lead Discovery<br />
Functional secondary assays for the FLIPR<br />
format: cAMP-AlphaScreen<br />
<strong>ABCD</strong><br />
GPCR<br />
α γ<br />
β<br />
ATP<br />
adenylate<br />
cyclase<br />
↑ Fsk<br />
cAMP<br />
680 nm<br />
520-620 nm<br />
biotin-cAMP<br />
Acceptor-Anti-cAMP<br />
Donor-SA<br />
Ralf Heilker<br />
Dep. of Integrated Lead Discovery
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