ABCD ABCD - Molecular Devices
ABCD ABCD - Molecular Devices
ABCD ABCD - Molecular Devices
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Correlation of non-specific hits from the<br />
antagonist versus the CHO counter screen<br />
<strong>ABCD</strong><br />
>90 % of the CHO-active hits are also active despite the presence of reference antagonist,<br />
which confirms their non-specific character<br />
Ralf Heilker<br />
Dep. of Integrated Lead Discovery<br />
EC50 determination/selectivity<br />
<strong>ABCD</strong><br />
• 7652 compounds underwent EC50 testing at the target molecule,<br />
GPCR X1 receptor<br />
• the same compounds underwent EC50 testing at the closest<br />
homologues: GPCR X2 and GPCR X3<br />
Ralf Heilker<br />
Dep. of Integrated Lead Discovery
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