The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM
The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM
The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM
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Klebsiella pneumoniae Carbapenemase (<strong>KPC</strong>)<br />
• First reported in 2001 from an isolate in NC<br />
• Very rapid spread<br />
• 10 variants (<strong>KPC</strong>-2 through <strong>KPC</strong>-11)<br />
• Endemic in Northeastern USA, Puerto Rico, Colombia,<br />
Israel, <strong>and</strong> Greece<br />
• K. pneumoniae, other Enterobacteriaceae,<br />
Acinetobacter, P. aeruginosa<br />
• <strong>ESBL</strong> that also hydrolyzes carbapenems<br />
• Extensive multidrug resistance
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