The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM
The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM
The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM
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Carbapenemases<br />
Class A (<strong>KPC</strong>, GES, SME etc.)<br />
Serine-based<br />
Hydrolyze all β-lactams (variability)<br />
Inhibited by clavulanate<br />
Class B (Metallo-β-<strong>lactamases</strong> - IMP, VIM, NDM etc.)<br />
Require zinc for activity<br />
Hydrolyze carbapenems rapidly<br />
Hydrolyze all β-lactams except aztreonam<br />
Resistant to clavulanate<br />
Class D (some OXAs)<br />
Poorly inhibited by clavulanate<br />
Acinetobacter, P. aeruginosa, some Enterobacteriaceae
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