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The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM

The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM

The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM

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Clinical Significance <strong>of</strong> <strong>AmpC</strong> for<br />

K. pneumoniae Bloodstream Isolates<br />

Clinical<br />

DHA-1<br />

(inducible)<br />

CMY-1 like<br />

Extended-spectrum<br />

Cephalosporin as<br />

definitive therapy<br />

Failed CTX/CAZ;<br />

improved on<br />

carbapenem<br />

4/4 died 1/3 died<br />

6 5<br />

30 day mortality 46% 14.3%<br />

DHA-1 (13 pts), CMY (14 pts) Pai et al. AAC 2004 48:3720-28

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