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The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM

The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM

The Evolving Threat of ESBL, AmpC, and KPC -lactamases - SWACM

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Many <strong>ESBL</strong> Producers Previously Reported<br />

Resistant to Cefepime Now “Susceptible”<br />

157 <strong>ESBL</strong>-positive<br />

E. coli, K. pneumoniae, K. oxytoca<br />

MIC in µg/ml<br />

< 8<br />

< 1<br />

% Susceptible<br />

77%<br />

34%<br />

63 U.S. Sites – <strong>ESBL</strong>-positive by phenotypic, IEF & molecular testing<br />

Mol<strong>and</strong>, Hanson, Black, Hossain, Song, & Thomson, 2006, J Clin Microbiol 44:3318-3324

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