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Supramolecular Chemistry for Nanosciences

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A Biological Rotary Motor: ATP Synthase<br />

α<br />

β<br />

β<br />

γ<br />

α<br />

β<br />

α<br />

3<br />

Rotor<br />

H +<br />

γ<br />

2<br />

H +<br />

Bent axle also rotates,<br />

squashing each βunit in<br />

turn<br />

H +<br />

H +<br />

H + H +<br />

H + H +<br />

H + H + H +<br />

H + H<br />

H + + H +<br />

C<br />

H + H +<br />

H +<br />

C<br />

1<br />

C<br />

C<br />

H +<br />

Stator<br />

H + H +<br />

H +<br />

H + H + H +<br />

• Driving <strong>for</strong>ce : proton gradient<br />

• The rotation produces chemical energy in the <strong>for</strong>m of ATP<br />

04/03/2008 M1-<strong>Nanosciences</strong><br />

T. Elston, , H. Wang, G. Oster,<br />

Nature, 1998, 391, , 510.<br />

14

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