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Annual Congress of Malaysian Thoracic Society
PP 20
Epidermal Growth Factor Receptor Mutations in Malaysian Patients
with Non-Small Cell Lung Cancer
H R Leow 1 , C K Liam 1 , Y K Pang 1 , K T Chua 1 , B K Lim 1 , C H Lee 1 ,
N L Lai 1 , P Jayalakshimi 2 , Pathmanathan R 3
1
Division of Respiratory Medicine, Department of Medicine, Faculty of Medicine,
University of Malaya, Kuala Lumpur, Malaysia
2
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
3
Pathology Laboratory, Sime Darby Medical Center, Subang Jaya, Malaysia
Introduction
There has been no report on the frequency of epidermal growth factor receptor (EGFR) mutations in Malaysian
patients with non-small cell lung cancer (NSCLC).
Objectives
To determine the frequency of EGFR mutations in NSCLC and to correlate the presence of EGFR mutation with
ethnicity, gender, age, smoking status and NSCLC cell type in Malaysian patients.
Patients and Methods
This is a prospective study on consecutive NSCLC patients who attended the University Malaya Medical
Centre. Mutations in the EGFR gene in pre-treatment NSCLC biopsy specimens were detected by direct DNA
sequencing.
Results
EGFR mutations were detected in 31 (43.1%) of a total of 72 patients with NSCLC - 21 (67.7%) had deletion
mutation in exon 19 and 10 (32.3%) had substitution mutation in exon 21. EGFR mutations were detected in 21
(63.6%) of 33 female compared to 10 (25.6%) of 39 male patients [odds ratio (OR), 2.48; 95% confidence interval
(CI), 1.37-4.49; p=0.003]. Twenty-three (60.5%) of 38 never smokers compared to 8 (23.5%) of 34 ever smokers
were mutation-positive (OR, 2.57; 95% CI, 1.33-4.97; p=0.033). Of 42 patients younger than 65 years, 22 (52.4%)
were mutation-positive compared to 9 (30%) of 30 patients aged 65 years or older (OR, 1.75; 95% CI, 0.94-
3.24; p=0.099). Mutation-positive patients were younger (mean age, 56.5 + 12.7 years) than mutation-negative
patients (mean age, 62.9 + 11.8 years) (p=0.029).
EGFR mutations was detected in 21 (39.6%) of 53 Chinese, 9 (52.9%) of 17 Malay and one (50%) of 2 Indian
patients. Mutations were detected in 28 (45.9%) of 62 adenocarcinoma, one (25%) of 4 squamous cell carcinoma,
none of adenosquamous carcinoma and large-cell carcinoma, and 2 (50%) of 4 NSCLC not otherwise specified
patients.
Conclusions
In Malaysian patients with NSCLC, EGFR mutations were significantly more common in female patients and in
never smokers. EGFR mutation-positive patients were significantly younger.
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