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Annual Congress of Malaysian Thoracic Society PP 17 Association Between Smoking, Lung Function, Obesity And Lipid Profile In Malaysian Subjects With Fasting Hyperglycemia B A Caszo, J V Gnanou, W H Wan Mohamad, H M Nawawi K Yusoff, T Ismail Faculty of Medicine, Universii Teknologi MARA, Selangor, Malaysia Introduction Obesity, type 2 diabetes mellitus and abnormal lipid profile are important components of metabolic syndrome. Reduced lung function can be a late complication of type 2 diabetes mellitus. Smoking and metabolic syndrome increase the risk of cardiovascular disease. Objectives To compare measures of obesity, lipid profile and lung function between smokers and non-smokers in Malaysian subjects with fasting hyperglycemia. Methodology Data was obtained from 1397 adult non-smokers and 553 smokers in a cross-sectional population based study. Non-smokers and smokers were classified based on these criteria; hyperglycemia with fasting blood glucose (FBS) >5.6 mmol/L, and abnormal lung function (ALF) < 70% FEV1, (ECCS prediction equation) into: Group 1: Normal lung function and Normoglycemia, Group 2: Normal lung function and Hyperglycemia, Group 3: ALF and Normoglycemia and Group 4: ALF and Hyperglycemia. Data expressed as mean ± SD was analysed using general linear model with SPSS 16.1 to compare across groups. Results Among non-smokers, as expected, hyperglycemic subjects (groups 2 and 4) had significantly higher body mass index (BMI), waist circumference and serum triglycerides than the normoglycemic subjects (group 1 and 3). However, among smokers no such difference was found between normoglycemic and hyperglycemic subjects, or those with normal of abnormal lung function. Conclusion Among non-smokers, BMI, waist circumference and high serum triglycerides were associated with hyperglycemia and not with ALF and this association was not present among smokers. This may imply that smoking has a greater influence on measures of obesity and lipid profile compared to the effect of hyperglycemia. 79
Annual Congress of Malaysian Thoracic Society PP 18 A Case Report: Management of Adenocarcinoma of Lung – Not Always Evidenced Based C A Tim, Irfhan Ali Respiratory Department, Penang Hospital, Penang, Malaysia Introduction Management of Adenocarcinoma of the lung has seen a magnitude of changes in recent years. Numerous studies have revolutionised management modalities. In practice though, often treating doctors use evidencebased treatments, but if lack of evidence, then it is normally very individualised treatment, depending on various factors. We report a case of a 64 year old lady, who was diagnosed as Stage IIIB adenocarcinoma of lung in May 2009, treated with two resections, 2 chemotherapy regimes and now doing very well on a tyrosine kinase inhibitor. This case illustrates the importance of multi-team approach, judicious use of imaging including PET / CT and understanding of treatment options by both treating physician and patient. 80
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