download - Malaysian Thoracic Society
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Annual Congress of <strong>Malaysian</strong> <strong>Thoracic</strong> <strong>Society</strong><br />
PP 17<br />
Association Between Smoking, Lung Function, Obesity And Lipid Profile<br />
In <strong>Malaysian</strong> Subjects With Fasting Hyperglycemia<br />
B A Caszo, J V Gnanou, W H Wan Mohamad, H M Nawawi K Yusoff, T Ismail<br />
Faculty of Medicine, Universii Teknologi MARA, Selangor, Malaysia<br />
Introduction<br />
Obesity, type 2 diabetes mellitus and abnormal lipid profile are important components of metabolic syndrome.<br />
Reduced lung function can be a late complication of type 2 diabetes mellitus. Smoking and metabolic syndrome<br />
increase the risk of cardiovascular disease.<br />
Objectives<br />
To compare measures of obesity, lipid profile and lung function between smokers and non-smokers in<br />
<strong>Malaysian</strong> subjects with fasting hyperglycemia.<br />
Methodology<br />
Data was obtained from 1397 adult non-smokers and 553 smokers in a cross-sectional population based study.<br />
Non-smokers and smokers were classified based on these criteria; hyperglycemia with fasting blood glucose<br />
(FBS) >5.6 mmol/L, and abnormal lung function (ALF) < 70% FEV1, (ECCS prediction equation) into: Group 1:<br />
Normal lung function and Normoglycemia, Group 2: Normal lung function and Hyperglycemia, Group 3: ALF<br />
and Normoglycemia and Group 4: ALF and Hyperglycemia. Data expressed as mean ± SD was analysed using<br />
general linear model with SPSS 16.1 to compare across groups.<br />
Results<br />
Among non-smokers, as expected, hyperglycemic subjects (groups 2 and 4) had significantly higher body<br />
mass index (BMI), waist circumference and serum triglycerides than the normoglycemic subjects (group 1<br />
and 3). However, among smokers no such difference was found between normoglycemic and hyperglycemic<br />
subjects, or those with normal of abnormal lung function.<br />
Conclusion<br />
Among non-smokers, BMI, waist circumference and high serum triglycerides were associated with<br />
hyperglycemia and not with ALF and this association was not present among smokers. This may imply<br />
that smoking has a greater influence on measures of obesity and lipid profile compared to the effect of<br />
hyperglycemia.<br />
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