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Annual Congress of Malaysian Thoracic Society Oral SCIENTIFIC PRESENTATIONS OP 6 MMP-9, UPA And SP-A As Sputum Biomarkers For COPD Severity 53 (SAFE Index) And Exacerbation Noor Ashikin M R 1 , Roslan H 1 , Azarisman M S 2 1 University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia 2 International Islamic University Malaysia, Kuala Lumpur, Malaysia OP 7 Procalcitonin-Aided Antibiotic Therapy Management In Hospital 54 – Acquired Pneumonia And Healthcare-Associated Pneumonia: A Randomised Controlled Trial Beni I R, Fauzi M A Norzailin A B, Shamsul A S, Nor Aini U, Roslina A M Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia OP 8 Correlation Between GINA-Defined Asthma Control, Asthma Control 55 Test And Lung Function Tests S Y Ooi, Y K Pang, C K Liam, K T Chua, C H Lee, B K Lim , N L Lai University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia OP 9 The Correlation Between COPD Assessment Test, FEV1, MMRC Scores 56 And 6MWT Harre Harren, Y K Pang, C K Liam, K T Chua, B K Lim, C H Lee, N L Lai University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia OP 10 Health-Related Quality Of Life Among COPD Patients In Universiti 57 Kebangsaan Malaysia Medical Center (UKMMC) Using New Assessment Tool – COPD Assessment Test (CAT) Hazman Jalil, Alia Suzana Asri, Huan Kai Poh, Ng Sock Wen, Ramlah Mohamad Kutty, Roslina A Manap Department of Internal Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia 47
Annual Congress of Malaysian Thoracic Society OP 1 The Effects Of Honey On The Inflammatory Process Of The Respiratory Tract Of Cigarette Smoke-Exposed Male Rats Tg Fatimah Murniwati T M 1 , Shaharudin A 2 , Zul Izhar M I 1 , T T Win 3 1 Anatomy Department, 2 Medical Department, 3 Pathology Department, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kota Bharu, Kelantan, Malaysia The most common risk factor for Chronic Obstructive Pulmonary Disease (COPD) is cigarette smoking. Inflammatory changes signify a clear indication in the early pathological changes of the airway in this disease. Recently, honey has been shown to have significant therapeutic properties. Its beneficial effect has been widely studied, but the study on the use of honey in COPD is limited. The main objective of this study was to evaluate the effect of honey on the inflammatory process in the small airways of rats exposed concurrently to cigarette smoke. This was determined by a quantitative study of the neutrophils, macrophages and CD8+ T lymphocytes in the interalveolar septum and a semiquantitative study of the morphological changes of the airway. Twenty-three male Sprague Dawley rats were divided into the control, smoking+honey and smoking only groups. The dose of honey given to the rats in the smoking+honey group was 1.2gm/kg body weight daily. The rats were sacrificed after four weeks of exposure. Immunohistochemical staining was performed using anti-CD68 and anti-CD8 to quantify the alveolar macrophages and the CD8+ T lymphocytes in the interalveolar septum respectively. Masson Trichrome staining was carried out for pathological scoring examination of the small airways. There was a significant reduction in the number of macrophage in the smoking+ honey group compared to smoking only group (z=-2.52, p= 0.036). However there was no significant reduction in the number of neutrophils (z=-0.54, p>1.00) and CD8+ T lymphocytes counts (z=-0.40, p>1.00) between these two groups. The pathological scores between the two groups were also not statistically different (z=-0.14, p=0.892). In conclusion, honey has a significant effect in reducing the macrophage recruitment in the respiratory tract following inflammatory response due to cigarette smoke inhalations in rats. Honey also shows a reducing trend in the recruitment of neutrophils and CD8+ T lymphocytes although it is not statistically significant. 48
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