download - Malaysian Thoracic Society
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Annual Congress of <strong>Malaysian</strong> <strong>Thoracic</strong> <strong>Society</strong><br />
Symposium 3A<br />
COPD<br />
Roles of Unconventional Therapy in Stable COPD<br />
Michael Joseph<br />
Malaysia<br />
COPD is a disease caused by inflammation triggered by noxious stimuli, primarily cigarette smoke in most cases.<br />
The inflammation is both local (pulmonary) & systemic, accounting for most of COPD’s manifestations.<br />
Therapies for COPD thus far (conventional or guideline-defined) have been proven in numerous large<br />
randomised trials to have benefits in improving symptoms & quality of life, preventing exacerbations &<br />
reducing mortality. However, despite these benefits, they still fall short in their ability to prevent progression<br />
of the disease. This is presumably due to incomplete resolution of the underlying inflammatory process.<br />
Thus, the search continues for the ultimate COPD therapy. In the process, several drugs have been found to<br />
have potential beneficial effects in COPD & may play a role in the future management of the disease. Robust<br />
evidence for these (unconventional) therapies is lacking though. The lecture will look at several of these<br />
therapies – statins, beta blockers, macrolide antibiotics & mucolytics- & discuss their potential roles in COPD<br />
management.<br />
Symposium 3A<br />
COPD<br />
Treatment beyond inhalers: Lung volume reduction surgery<br />
Anand Sachithanandan<br />
Malaysia<br />
Patients with end stage advanced emphysema have a poor quality of life and reduced survival. Historically,<br />
the only treatment has been pulmonary rehabilitation with medical therapy. Lung volume reduction surgery<br />
(LVRS) and lung transplantation are the two main surgical options potentially available to such patients.<br />
This lecture is a comprehensive overview of LVRS. The historical origin and evolution of the procedure, the<br />
rationale and principle of LVRS, indications for surgery, patient selection criteria, the evidence for LVRS,<br />
technical surgical considerations and early/midterm surgical outcomes including results from the seminal<br />
North American NETT trial will be discussed.<br />
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