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Annual Congress of <strong>Malaysian</strong> <strong>Thoracic</strong> <strong>Society</strong><br />

Symposium 3A<br />

COPD<br />

Roles of Unconventional Therapy in Stable COPD<br />

Michael Joseph<br />

Malaysia<br />

COPD is a disease caused by inflammation triggered by noxious stimuli, primarily cigarette smoke in most cases.<br />

The inflammation is both local (pulmonary) & systemic, accounting for most of COPD’s manifestations.<br />

Therapies for COPD thus far (conventional or guideline-defined) have been proven in numerous large<br />

randomised trials to have benefits in improving symptoms & quality of life, preventing exacerbations &<br />

reducing mortality. However, despite these benefits, they still fall short in their ability to prevent progression<br />

of the disease. This is presumably due to incomplete resolution of the underlying inflammatory process.<br />

Thus, the search continues for the ultimate COPD therapy. In the process, several drugs have been found to<br />

have potential beneficial effects in COPD & may play a role in the future management of the disease. Robust<br />

evidence for these (unconventional) therapies is lacking though. The lecture will look at several of these<br />

therapies – statins, beta blockers, macrolide antibiotics & mucolytics- & discuss their potential roles in COPD<br />

management.<br />

Symposium 3A<br />

COPD<br />

Treatment beyond inhalers: Lung volume reduction surgery<br />

Anand Sachithanandan<br />

Malaysia<br />

Patients with end stage advanced emphysema have a poor quality of life and reduced survival. Historically,<br />

the only treatment has been pulmonary rehabilitation with medical therapy. Lung volume reduction surgery<br />

(LVRS) and lung transplantation are the two main surgical options potentially available to such patients.<br />

This lecture is a comprehensive overview of LVRS. The historical origin and evolution of the procedure, the<br />

rationale and principle of LVRS, indications for surgery, patient selection criteria, the evidence for LVRS,<br />

technical surgical considerations and early/midterm surgical outcomes including results from the seminal<br />

North American NETT trial will be discussed.<br />

27

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