Ionix Pharmaceuticals - Molecular Devices

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Conclusions FLEXstation has been successfully used to… Develop assays that analyze voltage-gated calcium and sodium channels expressed in neuroblastoma cell lines Carry-out a medium throughput screen on voltage-gated calcium channels 30
Acknowledgements <strong>Molecular</strong> Pharmacology Group Dave Thomas Stuart Ward Kathryn Elsegood Zoe Gladwell 31
Page 1 and 2: Using the FLEXstation to investigat
Page 3 and 4: Ionix Profile Founded July 2001, C
Page 5 and 6: Voltage-gated Calcium Channels IMR
Page 7 and 8: IMR32 Cell Culture Conditions Cell
Page 9 and 10: Fura-2 Fluorescent Indicator 340/3
Page 11 and 12: KCl-Induced Calcium Changes In IMR-
Page 13 and 14: 1M Nicardipine +1M -CnTxGVIA 13 Pha
Page 15 and 16: Increasing CaCl 2 Concentration in
Page 17 and 18: Calcium Channel Screen 50,000 comp
Page 19 and 20: 19 SOFTmax PRO Data Analysis
Page 21 and 22: Summary Developed assay to analyze
Page 23 and 24: Experimental Conditions Neuroblast
Page 25 and 26: Assay Validation Responses measure
Page 27 and 28: Summary of Data Cell Line SH-SY-5Y
Page 29: Summary Tetrodotoxin sensitive vol

Ionix Pharmaceuticals - Molecular Devices

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