Ionix Pharmaceuticals - Molecular Devices

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Measuring Sodium Channel Responses FLEXstation Output 80000 Response (RFU) 60000 40000 Veratridine Max-Min Response 20000 0 25 50 75 100 Time (sec) 24
Assay Validation Responses measured in BE(2)C cells Veratridine Tetrodotoxin (100M Veratridine) 100000 100000 Response (RFU) 75000 50000 25000 Response (RFU) 75000 50000 25000 0 1 10 100 1000 0 0.01 0.1 1 10 100 1000 10000 Veratridine concentration (M) EC 50 = 13 M Tetrodotoxin concentration (nM) IC 50 = 6 nM 25
Page 1 and 2: Using the FLEXstation to investigat
Page 3 and 4: Ionix Profile Founded July 2001, C
Page 5 and 6: Voltage-gated Calcium Channels IMR
Page 7 and 8: IMR32 Cell Culture Conditions Cell
Page 9 and 10: Fura-2 Fluorescent Indicator 340/3
Page 11 and 12: KCl-Induced Calcium Changes In IMR-
Page 13 and 14: 1M Nicardipine +1M -CnTxGVIA 13 Pha
Page 15 and 16: Increasing CaCl 2 Concentration in
Page 17 and 18: Calcium Channel Screen 50,000 comp
Page 19 and 20: 19 SOFTmax PRO Data Analysis
Page 21 and 22: Summary Developed assay to analyze
Page 23: Experimental Conditions Neuroblast
Page 27 and 28: Summary of Data Cell Line SH-SY-5Y
Page 29 and 30: Summary Tetrodotoxin sensitive vol
Page 31: Acknowledgements Molecular Pharmac

Ionix Pharmaceuticals - Molecular Devices

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