Ionix Pharmaceuticals - Molecular Devices
Ionix Pharmaceuticals - Molecular Devices
Ionix Pharmaceuticals - Molecular Devices
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Assay Validation<br />
Calcium channel blockers were used to validate<br />
the assay<br />
Nimodipine<br />
-Conotoxin-GVIA<br />
Response (% Max)<br />
100<br />
75<br />
50<br />
25<br />
0<br />
Response (% Max)<br />
100<br />
75<br />
50<br />
25<br />
0<br />
0.0001 0.001 0.01 0.1 1 10 100 1000<br />
Nimodipine concentration (M)<br />
N-Type IC 50 = 5.3 M<br />
L-Type IC 50 = 13 nM<br />
1 10 100<br />
-Conotoxin-GVIA concentration<br />
(nM)<br />
N-type IC 50 = 5.5 nM<br />
L-type No Block<br />
16
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