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Ionix Pharmaceuticals - Molecular Devices

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Calcium Channel Assays<br />

N-Type Assay:<br />

8-10 day differentiated IMR32 cells<br />

Assay run in the presence of nitrendipine or<br />

nicardipine to block L-type component<br />

L-Type Assay (two strategies):<br />

8-10 day differentiated IMR32 cells<br />

Need to block N-type component with<br />

-conotoxin GVIA (expensive option)<br />

Undifferentiated IMR32 cells (preferred<br />

option)<br />

No N-type component<br />

12

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