dexin tab - Lomus Pharmaceuticals Pvt. Ltd.
dexin tab - Lomus Pharmaceuticals Pvt. Ltd. dexin tab - Lomus Pharmaceuticals Pvt. Ltd.
DEXI Tablet/Drops Dosage Forms/Composition Tablet: Each tablet contains Dexamethasone 0.5mg Drop: Each 5ml contains Dexamethasone 0.5mg Pharmacological Index Corticosteroid INDICATION Endocrine disorder, Rheumatic diseases, Collagen diseases, Dermatological diseases, Allergic states, Opthalmic diseases, Respiratory diseases, Hamatologic diseases, Neoplastic diseases, Edematous states, GIT diseases. Pregnancy Risk Factor C Contraindications Hypersensitivity to corticosteroid, cushing’s syndrome. Severe forms of heart insufficiency. Uncontrolled diabetes mellitus. Systemic tuberculosis. Severe systemic viral, bacterial, and fungal infections, ostreoporosis. Warnings/Precautions Hypothyroidism, cirrhosis, hypertension, CHF, ulcerative colitis, thromboembolic disorders, osteoporosis, glaucoma, cataract or TB of the eye, existing gastrointestinal ulceration, diabetes, elderly, children, adolescent, pregnancy, lactation. Monitor blood glucose levels in diabetics and coagulations indices in patients on warfarin. Adverse Reactions Systemic: >10%: Central nervous system: Insomnia, nervousness Gastrointestinal: Increased appetite, indigestion 1% to 10%: Dermatologic: Hirsutism Endocrine & metabolic: Diabetes mellitus Neuromuscular & skeletal: Arthralgia Ocular: Cataracts Respiratory: Epistaxis
DEXI Tablet/Drops<br />
Dosage Forms/Composition<br />
Tablet: Each <strong>tab</strong>let contains Dexamethasone 0.5mg<br />
Drop: Each 5ml contains Dexamethasone 0.5mg<br />
Pharmacological Index<br />
Corticosteroid<br />
INDICATION<br />
Endocrine disorder, Rheumatic diseases, Collagen diseases, Dermatological<br />
diseases, Allergic states, Opthalmic diseases, Respiratory diseases, Hamatologic<br />
diseases, Neoplastic diseases, Edematous states, GIT diseases.<br />
Pregnancy Risk Factor<br />
C<br />
Contraindications<br />
Hypersensitivity to corticosteroid, cushing’s syndrome. Severe forms of heart<br />
insufficiency. Uncontrolled diabetes mellitus. Systemic tuberculosis. Severe systemic<br />
viral, bacterial, and fungal infections, ostreoporosis.<br />
Warnings/Precautions<br />
Hypothyroidism, cirrhosis, hypertension, CHF, ulcerative colitis, thromboembolic<br />
disorders, osteoporosis, glaucoma, cataract or TB of the eye, existing gastrointestinal<br />
ulceration, diabetes, elderly, children, adolescent, pregnancy, lactation. Monitor blood<br />
glucose levels in diabetics and coagulations indices in patients on warfarin.<br />
Adverse Reactions<br />
Systemic:<br />
>10%:<br />
Central nervous system: Insomnia, nervousness<br />
Gastrointestinal: Increased appetite, indigestion<br />
1% to 10%:<br />
Dermatologic: Hirsutism<br />
Endocrine & me<strong>tab</strong>olic: Diabetes mellitus<br />
Neuromuscular & skeletal: Arthralgia<br />
Ocular: Cataracts<br />
Respiratory: Epistaxis<br />
Symptoms of overdose include moon face, central obesity, hypertension, psychosis,<br />
hallucinations, diabetes, hyperlipidemia, peptic ulcer, increased susceptibility to<br />
infection, electrolyte and fluid imbalance. When consumed in excessive quantities,<br />
systemic hypercorticism and adrenal suppression may occur; in those cases,<br />
discontinuation and withdrawal of the corticosteroid should be done judiciously.<br />
Drug Interactions<br />
CYP3A3/4 enzyme substrate; CYP3A3/4 enzyme inducer; CYP3A3/4 enzyme inhibitor.<br />
Mechanism of Action<br />
Decreases inflammation by suppression of migration of polymorphonuclear leukocytes<br />
and reversal of increased capillary permeability; suppresses normal immune response.<br />
Pharmacodynamics/Kinetics<br />
Duration of me<strong>tab</strong>olic effect: Can last for 72 hours; acetate is a long-acting repository<br />
preparation with a prompt onset of action.<br />
Me<strong>tab</strong>olism: In the liver<br />
Half-life: Normal renal function: 1.8-3.5 hours; Biological half-life: 36-54 hours<br />
Time to peak serum concentration: Oral: Within 1-2 hours; I.M.: Within 8 hours<br />
Elimination: In the urine and bile<br />
Usual Dosage<br />
0.5 to 1.5 mg per day.<br />
Avoid more than 1.5 mg daily, because serious side effects are more frequently<br />
encountered with higher doses.<br />
Patient Information<br />
Take exactly as directed; do not increase dose or discontinue abruptly without<br />
consulting prescriber. Take oral medication with or after meals. Limit intake of caffeine<br />
or stimulants. Prescriber may recommend increased dietary vitamins, minerals, or iron.<br />
Diabetics should monitor glucose levels closely (antidiabetic medication may need to<br />
be adjusted). Inform prescriber if you are experiencing greater than normal levels of<br />
stress (medication may need adjustment). Some forms of this medication may cause GI<br />
upset (oral medication may be taken with meals to reduce GI upset; small frequent<br />
meals and frequent mouth care may reduce GI upset). You may be more susceptible to<br />
infection (avoid crowds and persons with contagious or infective conditions). Report<br />
promptly excessive nervousness or sleep disturbances; any signs of infection (sore<br />
throat, unhealed injuries); excessive growth of body hair or loss of skin color; changes<br />
in vision; excessive or sudden weight gain (>3 lb/week); swelling of face or extremities;<br />
difficulty breathing; muscle weakness; change in color of stools (tarry) or persistent<br />
abdominal pain; or worsening of condition or failure to improve. Pregnancy/breastfeeding<br />
precautions: Inform prescriber if you are or intend to be pregnant. Consult<br />
prescriber if breast-feeding.<br />
LOMUS Drug Information Center<br />
<strong>Lomus</strong> <strong>Pharmaceuticals</strong> <strong>Pvt</strong>. <strong>Ltd</strong>.<br />
P.O. Box No 4506, <strong>Lomus</strong> House (Corporate office),<br />
Kailash Chour, Lazimpat, Kathmandu, Nepal<br />
Ph: 4436396 (Hunting Line). Fx: 977-1-4436395<br />
E-mail: druginfo@lomus.com.np
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