Haematologica 2003 - Supplements

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explore higher doses of zoledronic acid for patients with myeloma. These studies suggest the possibility that in the near future that bisphosphonates may not only be used to reduce skeletal complications but also treat the underlying myeloma itself. P9.4 OPTIMIZING TREATMENT FOR ANEMIA Heinz Ludwig Department of Medicine and Medical Oncology, Wilhelminenspital, Vienna, Austria Anemia is a frequent complication of myeloma and a negative prognostic factor. In several studies up to 60% of patients presented with hemoglobin
explore higher doses of zoledronic acid for patients with myeloma. These studies suggest the possibility that in the near future that bisphosphonates may not only be used to reduce skeletal complications but also treat the underlying myeloma itself. P9.4 OPTIMIZING TREATMENT FOR ANEMIA Heinz Ludwig Department of Medicine and Medical Oncology, Wilhelminenspital, Vienna, Austria Anemia is a frequent complication of myeloma and a negative prognostic factor. In several studies up to 60% of patients presented with hemoglobin
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Focussed Symposia Arsenic trioxide
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assess whether such a program will
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The overall response rate was noted
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Figure 5A Table 1: VEL + THAL for R
Page 9 and 10: naturally occurring OPG. Present tr
Page 11 and 12: 0.505). Finally, the multiple event
Page 13 and 14: CLINICOPATHOLOGICAL DEFINITION OF W
Page 15 and 16: Plenary Sessions 1. Development of
Page 17 and 18: clonotypic IgH VDJ signature confir
Page 19 and 20: can be considered as two entities,
Page 21 and 22: immunofluorescence staining for DKK
Page 23 and 24: P2.3 DEVELOPMENT OF A MULTIPLE MYEL
Page 25 and 26: P2.5 MOLECULAR CYTOGENETICS OF MYEL
Page 27 and 28: clear that the biggest challenge fo
Page 29 and 30: esponse and have demonstrated that
Page 31 and 32: variable region of the idiotypic im
Page 33 and 34: 4. From MGUS to symptomatic MM Fig.
Page 35 and 36: (MRI); some have claimed that level
Page 37 and 38: P4.5 CYTOKINES IN MGUS: THERAPEUTIC
Page 39 and 40: preventing phosphorylation of p70S6
Page 41 and 42: transducing component of the interl
Page 43 and 44: survive initial drug exposure and a
Page 45 and 46: quiescent counterpart, the human um
Page 47 and 48: transcriptional activity of NF-êB;
Page 49 and 50: manifestations and anomalous protei
Page 51 and 52: P7.4 ROLE OF SERUM FREE LIGHT CHAIN
Page 53 and 54: P7.6 IMMUNOPHENOTYPIC INVESTIGATION
Page 55 and 56: presumably through the circulation,
Page 57 and 58: 9. Chemotherapy, maintenance treatm
Page 59: stratified according to their antim
Page 63 and 64: initial therapy. However, the role
Page 65 and 66: P10.2.2 SINGLE VERSUS TANDEM HIGH D
Page 67 and 68: With a median follow-up of 38 month
Page 69 and 70: cells could be harvested following
Page 71 and 72: 11. What is the role of allogeneic
Page 73 and 74: found that 75% of patients who were
Page 75 and 76: patients with responsive disease 3
Page 77 and 78: 9. Giralt S, Estey E, Albitar M, et
Page 79 and 80: Badros A, Barlogie B, Siegel E, et
Page 81 and 82: Figure 3b. Event-free Survival 4-Ye
Page 83 and 84: improve patient outcome in MM. Impo
Page 85 and 86: myeloma and in 40% of previously un
Page 87 and 88: degrade OPG in the same way as myel
Page 89 and 90: P12.2.5 MONOCLONAL ANTIBODY THERAPY
Page 91 and 92: myeloma. Blood 2001; 98:210-216. 6.
Page 93 and 94: MHC molecules, in effectively prese
Page 95 and 96: mice demonstrate that class II-spec
Page 97 and 98: detected in 293 and NIH3T3 cells. S
Page 99 and 100: hypothesis that (1) CCND1 and FGFR3
Page 101 and 102: patient samples. In addition, the p
Page 103 and 104: 016 NEUTRAL ENDOPEPTIDASE (CD10) KN
Page 105 and 106: 2. Genetic heterogeneity in MM: imp
Page 107 and 108: evidence from two t(11;14) cases wh
Page 109 and 110: immunoglobulin heavy chain (IgH) lo
Page 111 and 112:
034 Instability of Pericentromeric
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clusters were found, the first was
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MGUS but most likely not crucial fo
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Objective: To compare the impact on
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4 patients had MMSET/IgH but did no
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and clonal PC from MGUS, MM and PCL
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059 VEGF receptor expresion in Mult
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two HLA-A2+ myeloma patients with C
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molecules expressed on the surface
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Recognition of these antigens appea
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Diagnosis requires a single area of
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081 Incidence of solid tumors in co
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Growth Factor (VEGF), Hepatocyte Gr
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PC-AI levels of MGUS and SMM patien
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093 The predominant pathway of tran
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was associated with I.V. line, whil
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103 Vascular amyloidosis induces se
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5. Signal transduction pathways and
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integrin in IGF-1-triggered MM cell
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118 IL-6- Induced Phosphorylation o
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123 THE IGF/IGF-1R SYSTEM IS A MAJO
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human myeloma cell line (HMCL) to a
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ligation or dexamethasone (Georgii-
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6. Role of microenvironment 6.1 Cel
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141 Human myeloma cells adhere to f
Page 161 and 162:
145 STUDY OF BONE MARROW ANGIOGENES
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patients, the growth of primary mye
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tibia (con=49.1±0.7mg/cm2 vs 5T2=4
Page 167 and 168:
157 The Nitrogen-Containing Bisphos
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7. New prognostic criteria for clas
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atio of >3. This system has subdivi
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Patient 1 (IgG/κ);IgG - 16.5 days,
Page 175 and 176:
176 Pro-inflammatory and angiogenic
Page 177 and 178:
180 Clinical study on the bone lesi
Page 179 and 180:
7.2 Imaging studies 185 99mTc-MIBI
Page 181 and 182:
189 Factors Predicting Occult Spina
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vivo detected resonances was invest
Page 185 and 186:
Support Unit (CTSU) with flexibilit
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(β2m) & C reactive protein (CRP).
Page 189 and 190:
plasmids carrying the clonotypic in
Page 191 and 192:
newly diagnosed multiple myeloma as
Page 193 and 194:
216 Transgenic expression of Myc an
Page 195 and 196:
221 Prolonged survival in the 5T2MM
Page 197 and 198:
9. Chemotherapy, maintenance, treat
Page 199 and 200:
229 EFFECTIVENESS OF STANDARD CHEMO
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234 Melphalan and Dexamethasone- Is
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Methods. We investigated the VECD p
Page 205 and 206:
9.2 Renal complications. 243 MERIT
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cost of SRE-related care was $10,24
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those with Hb >13 g/dL. Analysis of
Page 211 and 212:
sustained response, lasting from 52
Page 213 and 214:
proportion of bone abnormality. IgD
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disease. The lack of response to in
Page 217 and 218:
yielding a median of 3x106/kg CD34
Page 219 and 220:
patients(pts) aged ≥60 yrs. We co
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PBSC mobilizing regimen utilizing C
Page 223 and 224:
their leukocytes and platelets. No
Page 225 and 226:
25 Gy to marrow. The tracer dose wa
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non-CR after the first transplant a
Page 229 and 230:
296 PERIPHERAL BLOOD STEM CELL TRAN
Page 231 and 232:
References Effect of dose-intensive
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with cyclosporine A and methotrexat
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11.Role of novel therapies targetin
Page 237 and 238:
312 Thalidomide as Rescue of Relaps
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patients, light chain in 1 patients
Page 241 and 242:
platelets of 207 (76-402), B2M of 3
Page 243 and 244:
325 Low Dose Thalidomide plus Dexam
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in 5 pts (11%), M protein decreased
Page 247 and 248:
time from diagnosis was 3.7 years a
Page 249 and 250:
339 Thalidomide, Clarithromycin and
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344 COMBINATION OF THALIDOMIDE, DEX
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experienced early death during the
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untreated patients with high tumor
Page 257 and 258:
357 Thalidomide protects endothelia
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362 EOSINOPHILIA IS A VERY COMMON F
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11.5 CC 4047, PS 341 and arsenic tr
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without chromosome 13. Mean IC50 fo
Page 265 and 266:
myeloma patients. Phase I data indi
Page 267 and 268:
11.6 Other drugs 380 EFFECT OF STI5
Page 269 and 270:
significant inhibition of cell prol
Page 271 and 272:
which acts to prevent the synthesis
Page 273 and 274:
of B and its metabolites, however,
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and 10 months after start of therap
Page 277 and 278:
terminal kinase (JNK) pathway which
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lymphocytes was tested by Ellispot.
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411 Dendritic Cell-Based Idiotype V
Page 283 and 284:
Author Index Abe M 74 160 Abelman W
Page 285 and 286:
De La Serna J 291 De Laurenzi A P11
Page 287 and 288:
Hull DR 338 Hullen C P10.2.1 Humes
Page 289 and 290:
Morra E 249 280 359 Morris CM 226 M
Page 291 and 292:
Siegel D 70 115 250 Sierra J 304 30
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