Haematologica 2003 - Supplements

4. From MGUS to symptomatic MM
Fig.7 Hypothetical model of myeloma cell proliferation in the
bone marrow
REFERENCES
Harada H, et al: Phenotypic difference of normal plasma cells
from mature myeloma cells Blood 81:2658, 1993.
Kawano MM, et al: Identification of immature and mature
myeloma cells in the bone marrow of human myelomas Blood
82:564, 1993.
Huang N, et al: Heterogeneous expression of a novel MPC-1
antigen on myeloma cells Blood 82:3721,1993.
Mahmoud MS, et al: Induction of CD45 expression and
proliferation in U-266 myeloma cell line by interleukin-6
Blood 92:3887, 1998.
Ishikawa H, et al: Requirements of src family kinase activity
associated with CD45 for myeloma cell proliferation by
interleukin-6. Blood 99:2172, 2002.
P4.1
CRITERIA FOR THE CLASSIFICATION OF
MONOCLONAL GAMMOPATHIES, MULTIPLE
MYELOMA, AND RELATED DISORDERS: A REPORT
OF THE INTERNATIONAL MYELOMA WORKING
GROUP
Kyle RA, Child JA, et al.
The monoclonal gammopathies are a group of disorders
associated with monoclonal proliferation of plasma cells. The
characterisation of specific entities is an area of difficulty in
clinical practice. The International Myeloma Working Group has
reviewed the criteria for diagnosis and classification with the aim
of producing simple, easily used definitions based on routinely
available investigations. In monoclonal gammopathy of
undetermined significance (MGUS) or monoclonal gammopathy,
unattributed/unassociated (MG[u]) the monoclonal protein is